目的:探讨凝血分子标记物在子痫前期发病中的作用.方法:使用SYSMEX CA7000全自动血凝分析系统检测27例正常妊娠妇女(A组)和102例妊娠期高血压疾病患者[单纯妊娠期高血压及轻度子痫前期(B组)45例,重度子痫前期(C组)57例]的活化部分凝血酶时间(APTT)、凝血酶时间(PT)、纤维蛋白原(FIB)、抗凝血酶(AT)活性和血管性血友病因子(vWF).结果:①C组AT活性低于A组和8组,差异有统计学意义(P<0.05),而A组与B组的AT活性比较差异无统计学意义(P>0.05).②C组vWF水平高于A组和B组,差异有统计学意义(P<0.05),而A组与B组的vWF水平差异无统计学意义(P>0.05).③A组与B组、C组出凝血功能指标(PT,APTT和FIB)差异无统计学意义(P>0.05).④重度子痫前期并发症组(n=40)AT活性低于无并发症组(17例),差异有统计学意义(P<0.05),vWF水平高于无并发症组,差异有统计学意义(P<0.05).结论:联合监测vWF和AT水平有助于观察子痫前期的发生、发展情况,用以指导临床药物的使用,改善子痫前期患者的预后.%Objective: To observe the markers of coagulation vWF and AT in the pathogenesis of pre-eclampsia and to explore its clinical treatment value. Methods: Using the SYSMEX CAT000 automated hematology analyzer in 27 normal pregnant women and 102 gestational hypertension women to detect the markers, including the part activation thrombin fime(APTF), prothrombin time(PT), anfithrombin (AT) ,yon Willebrand factor(vWF). Results: ①The activityof AT in the severe eclampsism is lower than that in the mild and the control group. The difference have statistical significance (P ＜ 0.05 ). No statistical significance between the control and mild group (P ＞ 0.05 ). ②The activity- of vWF in the severe eclampsism group is higher than that in the mild and the control group, which have statistically significant(P ＜ 0.05 ) .No statistical significance between the control and the mild group (P ＞ 0.05 ). ③The differences of PT, APTT, FIB among the control group,the mild group and the severe group are not statistically significant(P ＞0.05). ④The AT level of the complications group is significant lower than that of complications group (P ＜ 0.05).The activity- of vWF is significantly higher than that of no complications (P ＜ 0.05). Conclusions: Monitoring vWF, AT levels contribute to early diagnosis of severe preeclampsia, guide the use of drugs, and improve the prognosis of patient.
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