子痫前期相关微小RNA的研究进展

摘要

子痫前期(preeclampsia,PE)是妊娠20周后出现的特发性高血压综合征,其病因和发病机制至今仍未完全阐明.微小RNA(microRNA,miRNA)是一类内源性的单链非编码RNA.新近研究证实,PE胎盘中存在异常表达的miRNA,分析母体血清miRNA表达谱有助于PE的早期预测,进一步研究PE相关miRNA及其靶基因的功能可能有助于阐明PE的发病机制,进而为PE的预防和治疗提供新思路.综述新近发现的与PE密切相关的miRNA的研究进展.%Preeclampsia-eclampsia is a serious pregnancy complication, endangering mother and fetus. The typical symptoms of preeclampsia includes hypertension and proteinuria. However,in recent years,studies suggest that preeclampsia -eclampsia is just like other syndromes with many atypical presentations. As a result, it is important that clinicians make timely and accurate diagnosis to prevent adverse maternal and fetal outcomes associated with these syndromes. The manifestation, diagnosis and treatment of the atypical preeclampsia-eclampsia will be discussed in this review. The object is to increase awareness of these atypical features of preeclampsia-eclampsia.and to improve early diagnosis and treatment of the patients with atypical features.