新辅助化疗在宫颈癌治疗中的作用

摘要

新辅助化疗的概念于1983年首次提出。目前新辅助化疗在宫颈癌治疗方面虽仍有争议，但随着医疗技术的不断发展其作用优势逐步显现。新辅助化疗不但可以缩小肿瘤体积、提高手术切除率，而且可延长妊娠期宫颈癌患者的妊娠时间，使其获得存活新生儿。故新辅助化疗的出现为局部晚期宫颈癌患者、晚期宫颈癌患者和妊娠期宫颈癌患者的治疗提供了新的思路。综述新辅助化疗概念的提出、所存争议、作用机制及其在宫颈癌综合治疗中的作用。%The concept of neoadjuvant chemotherapy was first proposed in 1983. Currently ,although there is argument in the role of neoadjuvant chemotherapy in the treatment of cervical cancer ,the potential advantage of neoadjuvant chemotherapy is apparent gradually by the development of the operation skills and methods. It can effectively reduce tumor volume ,increase the success rate of operation,and it can also delay the delivery until fetal viability has been reached. Neoadjuvant chemotherapy is one of the new therapeutic method for locally advanced cervical cancer ,advanced cervical cancer and cervical cancer patients during pregnancy. In this essay,the concept,argument,mechanism and the role of neoadjuvant chemotherapy in the treatment of cervical cancer were reviewed.