生物陶瓷表面纳米结构能够影响成骨细胞增殖和分化,其表面微观结构的控制,特别是烧结前晶粒取向调控,是设计开发生物活性陶瓷的关键之一.针对羟基磷灰石晶粒取向调控问题,重点研究了铁掺杂羟基磷灰石晶体在强磁场中的取向.分别采用共沉淀法和共沉淀-水热法合成了羟基磷灰石(HA)和铁-羟基磷灰石(Fe-HA),通过XRD、SEM、TEM、PPMS和ICP等对HA和Fe-HA的物相、微观形貌、磁学性能、元素组成进行了表征和分析.研究发现:Fe-HA物相与HA相同,没有明显的杂质相;HA为抗磁性,Fe-HA转化为顺磁性;共沉淀法粉体为针状,共沉淀-水热法粉体为短棒状,针状粉体在强磁场中不能定向,短棒状粉体能够定向;在单一方向强磁场中,HA不能单轴定向,Fe-HA能够在一定程度上沿c轴取向.%Thesurface nanostructure of bioceramics can affect osteoblast proliferation and differentiation, therefore the control of the surface microstructure of bioceramics, especially grain orientation before the ceramic sintering, is one of key to design and develop bioactive ceramics for bone regeneration. This study aimed to investigate the crystal orientation of Fe-doped hydroxyapatite in high magnetic field. Pure hydroxyapatite (HA) and Fe-doped hydroxyapa-tite (Fe-HA) powders were prepared by co-precipitation method and co-precipitation-hydrothermal method, and their phase composition, microstructure, magnetic property, and elementary composition were analyzed by XRD, SEM, TEM, PPMS, and ICP. The results showed that the phase of Fe-HA is the same as HA with no impurity phase. HA is diamagnetic originally, while Fe-HA becomes paramagnetic. The microstructure of samples prepared by co-precipitation method is needle cluster-like but that prepared by co-precipitation-hydrothermal method is rod-like. It is the rad-like but not the needle cluster-like Fe-HA can be orientated in high magnetic field. Therefore, the ori-entation of rod-like Fe-HA can be regulated by high magnetic field. Furthermore, pure HA cannot be uniaxial ori-entated in single-directed high magnetic field. while Fe-HA can be oriented alongc axis in certain degree in single- directed high magnetic field.
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