脑溢安对出血性中风大鼠脑内磷酸化蛋白激酶表达的影响

摘要

To investigate the effect of traditional Chinese medicine Nao Yi An (NYA) on the expression of P-C-Jun in the brain of experimental intracerebral hemorrhagic rat.The rats were randomly divided into the normal control group,the model control group and NYA treatment group.By injecting collagenase type Ⅶ stereotaxically into the right globas pallidus,rat models with haemorrhagic stroke were made.We investigated the changes of the expression of P-CJun in the piriform cortex of the rats.Results：The expression of P-C-Jun in NYA group was weaker than that in the model control group(P＜0.05).Conclusion：NYA interferes in the expression of P-C-Jun in the brain of rat models with haemorrhagic stroke，and affects the MAPK signal transduction.%探讨脑溢安对出血性中风大鼠脑内磷酸化蛋白激酶(P-C-Jun)表达的影响和治疗机理。根据Roserberg法复制大鼠脑出血模型，采用免疫组织化学方法观察脑出血后梨状皮质内P-C-Jun的表达变化，并用组织病理学方法分析脑皮质内神经元的损伤状况。结果：脑溢安治疗组较模型组脑内P-C-Jun蛋白表达弱，神经元受损状况轻。结论：脑溢安下调脑内P-C-Jun蛋白表达，从而干预了丝裂原活化的蛋白激酶(MAPK)信号转导通路。