滋肾活血方对血管性痴呆大鼠学习记忆能力和海马形态学的影响

摘要

Objective To explore the influence of Zishen Huoxue decoction on learning and memory ability and morphology of hippocampus in rats with vascular dementia (VD) rats. Methods The VD model rats were established by improved 2-VO method, and the rats were intervened by Zishen Huoxue decoction. After 4 weeks later, the changes of behavior were observed through water maze test, the hippocampal pathologic changes of rats were observed by HE staining. Results Compared with the model group,the escape latency of the Zishen Huoxue group reduced (P<0.05), the number of crossing platform increased (P<0.05), and the damage of hippocampal nerve cell relieved obviously. Conclusion Zishen Huoxue decoction could improve the learning and memory ability and reduce the pathological damage in hippocampal tissue of VD rats.%目的 探讨滋肾活血方对血管性痴呆(vascular dementia,VD)大鼠行为学和海马病理形态学的影响.方法 采用改良的双侧颈总动脉结扎法(2-VO法)制作VD大鼠模型,用滋肾活血方干预.给药4周后,用水迷宫检测行为学;HE染色观察海马病理形态学的改变.结果 与模型组相比,滋肾活血组逃避潜伏期缩短(P<0.05),跨越平台次数增多(P<0.05),HE染色示海马损伤明显减轻.结论 滋肾活血方可以改善VD大鼠的学习记忆能力,减轻海马组织损伤,对VD大鼠有一定的治疗作用.