补充微量营养素对HIV感染者/AIDS病人免疫功能的影响

摘要

目的:探讨补充微量营养素对HIV感染者及AIDS病人免疫功能的影响.方法:100例HIV感染者和100例AIDS病人分别随机分为研究组和对照组,每组50例.采用双盲法,研究组给予微量营养素片,1片/d,持续口服6个月.对照组给予安慰剂片,1片/d,持续口服6个月.各组干预前、干预6个月后分别采集静脉血,经全自动生化分析仪检测全血总蛋白、白蛋白水平;原子吸收分光光度法检测血清镁、锌、铁、钙水平;流式细胞检测仪检测血中CD3+、CD4+、CD8+T淋巴细胞;ELISA法检测血中IgA、IgG、IgM水平.结果:HIV感染者干预后血浆总蛋白、白蛋白水平均明显高于干预前.HIV感染者研究组干预后血清锌、钙、镁、铁含量均明显高于干预前及对照组;研究组干预后血中CD3+、CD4+、CD8+T淋巴细胞水平明显高于干预前及对照组干预后.AIDS患者研究组干预后血清锌、钙、镁、铁含量均明显高于干预前及对照组干预后;研究组与对照组干预前后血中CD3+、CD4+、CD8+T淋巴细胞、IgA、IgG、IgM水平均无统计学差异.结论:通过补充微量营养素,能明显提高HIV感染者及AIDS患者血中微量元素水平;可明显提高HIV感染者血中免疫细胞数量及血浆总蛋白、白蛋白水平.但是对AIDS患者免疫功能、血浆总蛋白、白蛋白水平则无显著影响.%Objective Explore the micronutrient supplementation on immune function of HIV/AIDS patients.Methods100 cases of HIV infected people and AIDS patients in100 cases were randomly divided into research group and the control group, 50 cases in each group. The double-blind method is adopted, the research group give micronutrients,1 / d, continuous oral for six months. The control group given a placebo tablets,1 / d, continuous oral for six months. Before each intervention, interven-tion6 months after venous blood was collected respectively, by the automatic biochemical analyzer test whole blood total protein and albumin levels; Atomic absorption spectrophotometry to detect the serum magnesium, zinc, iron, calcium level; Flow cy-tometry detector to detect blood CD3 +, CD4 +, CD8 + T lymphocytes; ELISA method to detect the blood of IgA, IgG, IgM level. Results People living with HIV intervention after the plasma total protein and albumin levels were significantly higher than that of before intervention. Inresearch group, after the intervention of serum zinc, calcium, magnesium, ironwere significantly higher than before the intervention and control group The research group after the intervention of blood CD3 +, CD4 +, CD8 + T lym-phocytes level obviously is higher than before the intervention and control group. AIDS patients group after the intervention of serum zinc, calcium, magnesium, iron were significantly higher than before the intervention and control group Blood group and the control group before and after the intervention of CD3 +, CD4 +, CD8 + T lymphocytes, IgA, IgG, IgM level had no statistical difference.ConclusionsThrough the micronutrient supplementation, can obviously increase the HIV infection and AIDS pa-tients' blood level of trace elements. It can obviously increase the number of people living with HIV immune cells in the blood and plasma total protein and albumin levels. But on the immune function of patients with AIDS, plasma total protein and albu-min levels had no significant effect.