妊娠高血压疾病患者胱抑素C、超敏C反应蛋白及同型半胱氨酸水平的变化及其诊断价值分析

摘要

目的:探讨妊娠高血压疾病患者胱抑素C(CysC)、超敏C反应蛋白(hs-CRP)及同型半胱氨酸(Hcy)水平的变化及其诊断价值.方法:选择2015年5年~2017年7月本院收治的120例妊娠高血压疾病患者为观察组,并同期选择本院收治的150例正常妊娠孕妇作为对照组.比较两组患者CysC、hs-CRP及Hcy水平及妊娠结果,并进行Logistic回归分析.结果:观察组患者CysC、hs-CRP及Hcy水平分别为(1.68±0.41)mg/L、(14.58±0.59)mg/L、(20.65±1.12)μmol/L,均显著高于对照组患者(0.85±0.35)mg/L、(3.43±0.37)mg/L、(8.27±0.98)μmol/L,组间差异有统计学意义.重度妊娠高血压患者CysC、hs-CRP及Hcy水平高于轻度、中度患者,中度妊娠高血压患者CysC、hs-CRP及Hcy水平高于轻度患者,三组差异比较有统计学意义.观察组患者早产、胎儿窘迫及围产儿死亡分别占20.00%、29.17%、16.67%,显著高于对照组患者5.33%、10.00%、2.67%,组间差异比较有统计学意义.Logistic回归分析中,妊娠期高血压疾病为因变量,自变量为CysC、hs-CRP及Hcy,结果表明CysC、hs-CRP及Hcy与妊娠期高血压疾病相关,差异有统计学意义.结论:妊娠高血压疾病患者的CysC、hs-CRP及Hcy水平随着病情加重不断升高,是该疾病的相关敏感指标,具有重要的临床诊断价值.%Objective To investigate the changes of cystatin C (CysC), hypersensitive C reactive protein (hs-CRP) and ho-mocysteine (Hcy) levels in patients with pregnancy induced hypertension and their diagnostic value. Methods Choose 5 years, 2017 to July 2015 in our hospital treated 120 cases of patients with pregnancy-induced hypertension disease as the observa-tion group, and at the same time choose in our hospital treated 150 cases of normal pregnancy pregnant women as control group. Compare two groups of patients with CysC, hs CRP and Hcy levels and pregnancy outcomes, and Logistic regression analysis. Results The CysC, hs - CRP and Hcy levels of observation group patientsr espectively were (1.68±0.41) mg/L、 (14.58±0.59) mg/L、 (20.65±1.12)μmol/L, the patients were significantly higher than the level of the control group (0.85±0.35) mg/L、 (3.43 ±0.37) mg/L、 (8.27±0.98)μmol/L, the difference between groups was statistically significant. Patients with severe pregnancy-induced hypertension CysC, hs - CRP and Hcy levels higher than that of patients with mild, moderate, mild gestational hyper-tension CysC, hs - CRP and Hcy levels higher than that of patients with mild, the comparison group difference was statistically significant. Observation group of patients with premature delivery, fetal distress and the perinatal death accounted for 20.00%, 29.17% and 29.17%, respectively, significantly higher than that of control group patients were 5.33%, 5.33%, 10.00%, diff be-tween groups was statistically significant. Logistic regression analysis, gestational hypertension disease as the dependent varia-ble, independent variable for CysC, hs - CRP and Hcy, the results show that CysC, hs - CRP and Hcy is associated with gesta-tional hypertension disease difference was statistically significant. Conclusion He levels of CysC, hs-CRP and Hcy in patients with pregnancy induced hypertension are increasing with the aggravation of the disease. It is a sensitive index of the disease, and has important clinical diagnostic value.