青年男性雄激素性秃发与动脉粥样硬化危险因素的相关性研究

摘要

Objective To analyze the correlation between androgenetic alopecia and atherosclerosis . Methods Blood pressure (BP), body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol ( LDL-C) , high-density lipoprotein cholesterol ( HDL-C) , TC/HDL-C, LDL-C/HDL-C, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), ApoB/ApoA1, fasting plasma glucose ( FPG) , high-sensitivity C-reactive protein ( hs-CRP) and other clinical indicators in 144 cases of young men (18~35 years) with androgenetic alopecia(case group) and 60 cases of non-bald physical examinees(control group) were detected.Flow-mediated dilatation (FMD), pulse wave velocity (BaPWV) and aorta compli-ance/arterial compliance ( C1/C2 ) were compared .The association between androgenetic alopecia and athero-sclerosis was investigated by case-control study.Results Case group had higher BP, BMT, TC, LDL-C, TC/HDL-C, LDL-C/HDL-C, ApoB, ApoB/ApoA1, BaPWV and lower FMD than control group (P<0.05).Con-clusion There is a correlation between androgenetic alopecia and atherosclerosis in young men .%目的：分析雄激素性秃发与动脉粥样硬化危险因素之间的相关性，探索雄激素性秃发成为动脉粥样硬化的早期预警信号的可能性。方法采用病例对照研究方法，比较62例雄激素性秃发患者与60例无秃发的健康体检者体重指数（ BMI）、血压（ BP）、总胆固醇（ TC）、甘油三酯（ TG）、低密度脂蛋白胆固醇（LDL -C）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）、脂蛋白a （Lp（a））、载脂蛋白E（ApoE）、空腹血糖（ FPG）、超敏C反应蛋白（ hs-CRP）等动脉粥样硬化危险因素，分析两组反应血管弹性的超声前臂反应性充血试验（ FMD）、脉搏波传导速度（ BaPWV）、大动脉顺应性/小动脉顺应性（C 1/C2）等动脉粥样硬化早期诊断指标。结果雄激素性秃发患者 BMI、BP、TC、LDL-C、TC/HDL-C、LDL-CH/DL -C、ApoB、ApoB/ApoA1及BaPWV较无秃发的健康体检者均明显增高，而FMD明显降低。结论青年男性雄激素性秃发与动脉粥样硬化之间存在一定的相关性，雄激素性秃发可能是动脉粥样硬化血管疾病早期预警信号之一。