Expression of mi RNA-630 in Bladder Urothelial Carcinoma and Its Clinical Significance

摘要

Many studies informed that micro RNAs(mi RNAs) could function as diagnostic and prognostic indicators in several cancers. The aims of this study were to explore the expression of mi R-630 in bladder urothelial carcinoma and its clinical significance for the evaluation of cancer prognosis. A total of 116 patients with bladder urothelial carcinoma were obtained in this retrospective study between May, 2012 and Sep. 2015. Quantitative real-time PCR(q RT-PCR) was conducted to evaluate the expression level of mi R-630. The chi-square test was used to examine the associations between mi R-630 expression and the clinicopathological features. The Kaplan-Meier method was conducted to explore the survival status of urothelial carcinoma patients. The log-rank test was used to analyze differences in survival rate. The results showed an obvious increase in mi R-630 expression from normal bladder to bladder urothelial carcinoma(P=0.027). Additionally, patients with higher mi R-630 expression had significantly shorter disease-free survival(DFS)(P=0.043) and overall survival(OS)(P=0.038) than those with lower mi R-630 expression. Furthermore, multivariate analysis revealed that up-regulation of mi R-630 was an independent prognostic factor for both DFS(P=0.042) and OS(P=0.046). It was demonstrated that mi R-630 may be a novel and valuable prognostic factor for bladder urothelial carcinoma.