派瑞松联合丹参酮治疗面部脂溢性皮炎的临床效果研究

摘要

Objective To investigate the clinical effects of pevisone combined with Tanshinone in the treatment of facial seborrheic dermatitis,so as to offer the excellent scheme for clinic treatment.Methods One hundred twenty patients suffered from facial seborrheic dermatitis who were coincident with research standard were selected and were divided into observation group and control group in accordance with random number table,60 patients for each group.For patients in control group,pevisone was offered only while for those in observation group,Tanshinone was provided in addition to pevisone treatment.The symptom improvement and effects of patients in two groups on the 2 nd and 4 th weekends after pharmacy were compared.The follow-up visit was carried out after the treatment for 4 weeks,during which the recurrence rate and adverse reactions were also compared.Results The scores of erythema,pruritus,desquamation and psoriasis area of patients in two groups showed a decreasing trend,and the scores of erythema,pruritus,desquamation and psoriasis area of patients in observation group were lower than those of control group,the interactions regarding groups,time points and groups and time points had statistical significance(P＜0.05).The average drug onset time of observation group was obviously shorter than that of control group,the treatment effect was better than that of control group yet the recurrence rate was obviously lower than that of control group(P＜0.05).The difference of adverse reaction incidence rates of two groups had no statistical significance(P＜0.05).Conclusion Pevisone combined with Tanshinone has favorable effects in the treatment of facial seborrheic dermatitis with such contributions as improved clinical symptoms,less adverse reactions and reduced recurrence rate,which should be widely promoted in clinical practice and applied as the preferred option.%目的 观察派瑞松联合丹参酮治疗面部脂溢性皮炎的临床效果,为临床治疗提供优质方案.方法 选择符合研究标准的面部脂溢性皮炎患者120例,按随机数字表法分为观察组与对照组,每组60例.对照组单纯给予派瑞松治疗,观察组在派瑞松治疗的基础上联合丹参酮治疗,比较用药后第2周末及第4周末2组患者症状改善及疗效,4周治疗结束后随访,比较随访复发率及不良反应.结果 2组红斑、瘙痒、脱屑以及皮损面积评分均呈降低的趋势,且观察组红斑、瘙痒、脱屑及皮损面积评分均低于对照组,其组间、时点间、组间·时点间交互作用差异有统计学意义(P＜0.05).观察组用药平均起效时间明显短于对照组,治疗效果优于对照组,复发率明显低于对照组(P＜0.05).2组不良反应发生率差异无统计学意义(P＜0.05).结论 派瑞松联合丹参酮治疗面部脂溢性皮炎,疗效佳,症状改善明显,不良反应少,复发率低,可在临床推广并作为首选方案给予应用.