线虫脂肪模型研究

摘要

Obesity is a kind of chronic disease with the fatty acid accumulation increased . Studying on the model of organism can discover the obesity disease -causing genes or related pathogenic factors , and find potential drug targets .The progress of research on Caenorhabdi-tis elegans as a model for fatty was summarized in this paper .The key genes and core path-ways in fatty acid metabolism was involved .The data obtained in Caenorhabditis elegans on fatty storage control will contribute largely to the study on metabolism related diseases , such as obesity in human beings .C.elegans may be invaluable in the development of reducing fat and body weightdrugs in the future .%肥胖是一种脂肪酸积累增加的慢性疾病，采用研究模式生物的方法可以有助于探明肥胖产生的致病基因或致病相关因子，进而寻找可能的药物靶点。综述了国内外对线虫脂肪模型的研究进展，分析了线虫体内脂肪酸代谢途径的关键基因和核心通路。线虫脂肪代谢调节研究工作对人类肥胖症等代谢疾病的研究具有重要的提示作用，利用线虫脂肪模型研究降脂减肥药物具有广阔的应用前景。