制备卡托普利-地高辛缓速释双层片并建立双层片中含两种主药量的测定方法.以羟丙甲基纤维素、微晶纤维素为辅料制备卡托普利缓释层;以低取代羟丙基纤维素为辅料,采用空白颗粒法制备地高辛速释层.采用高效液相色谱法测定百分含量.卡托普利和地高辛检测波长为220 nm,地高辛回归方程:y=22.665x+23.632,在40~200μg/mL的质量浓度范围内,线性良好;卡托普利回归方程:y=9.2601x+355.72,在0.15~0.75 mg/mL的质量浓度范围内,线性良好.本方法专属性强,精密度、回收率良好,可用于该制剂中含两种主药的测定.%To prepare captopril sustained release -digoxin rapid release double -layer tablet and establish content determination method .Captopril sustained release layer was prepared with hydroxy propyl methyl cellulose and microcrystalline cellulose as main adjuvants .Digox-in rapid release layer was prepared by the method of blank pellet with low -substituted hydroxypropyl cellulose .A high performance liquid chromatography method ( HPLC ) was used for the content assaying . The detective wave length of captopril and digoxin was 220nm.The regression equations and linear ranges of digoxin and captopril were:y=22.665x+23.632, 40~200μg/mL;y=9.2601x+355.72, 0.15~0.75 mg/mL, they had a good linear relationship .The method has good specificity , precision and recovery .It can be used to detect the digoxin and captopril drug content .
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