噻托溴铵联合舒利迭对 COPD 急性发作期患者血清炎症因子及血气指标的影响

摘要

[ABSTRACT]Objective:To observe the effects of tiotropium bromide combined with seretide on serum inflammatory fac-tors and blood gas indexes in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods:A total of 92 cases of COPD in acute exacerbation were randomly divided into observation group (47 cases)and control group (45 cases).The control group was given seretide on the basis of routine treatment,the observation group was given tiotropium bro-mide on the basis of the control group.After treatment for 2 weeks,changes of inflammatory factors (IL-6,IL-1 7,hs-CRP, TNF-α)and blood gas indexes (PaO 2 ,PaCO 2 ,PH value)were observed in two groups.Results:After treatment,compared with intra-group before treatment,levels of IL-6,IL-1 7,hs-CRP,TNF-αdecreased in both groups (P <0.05),the levels of PaO 2 and PH value increased and PaCO 2 decreased in both groups (P <0.05),levels of IL-6,IL-1 7,CRP,TNF-α,and PaCO2 in observation group were (7.1 5±3.30)ng/mL,(8.85±3.03)ng/mL,(5.24±2.58)mg/L,(1 68.85±48.22)pg/mL and (48. 76±7.54)mmHg,respectively,which were significantly lower than those in the control group after treatment,the difference were statistically significant (P <0.05),levels of PaO 2 and PH in observation group were (81.1 5 ± 9.70)mmHg and 7.40 ± 0.05,respectively,which were significantly higher than those in the control group after treatment,the difference were statisti-cally significant (P <0.05).Conclusion:Tiotropium bromide combined with seretide in the treatment of COPD during exacer-bated period can inhibit inflammatory reaction and improve blood gas indexes,which was more effective than seretide used a-lone.%目的：：观察噻托溴铵联合舒利迭对慢性阻塞性肺疾病(COPD)急性发作期患者血清炎症因子及血气指标的影响.方法：将92例 COPD 急性发作期病例随机分为观察组(47例)和对照组(45例).对照组在常规治疗的基础上给予舒利迭,观察组在对照组的基础上给予噻托溴铵.治疗2周,观察两组炎症因子(IL-6、IL-17、hs-CRP、TNF-α)及血气指标(PaO 2、PaCO 2、PH 值)的变化.结果：两组治疗后IL-6、IL-17、hs-CRP、TNF-α较本组治疗前下降,差异具有统计学意义(P ＜0．05)；两组 PaO 2、PH 值较本组治疗前上升而 PaCO 2下降,差异具有统计学意义(P ＜0．05)；观察组治疗后 IL-6、IL-17、CRP、TNF-α、PaCO 2均显著低于对照组治疗后,PaO 2、PH 值显著高于对照组治疗后,差异均具有统计学意义(P ＜0．05).结论：COPD 急性发作期联合应用噻托溴铵与舒利迭抑制炎症反应、改善血气指标作用显著,优于单用舒利迭.