瞬时弹性超声技术对药物性肝损伤患者肝纤维化、肝功能的评估价值

摘要

Objective:Objective:To study the value of transient ultrasonic elastography for evaluating the liver fibrosis and liver function in patients with drug-induced liver injury. Methods:68 patients with drug-induced liver injury who were trea-ted in our hospital between January 2O16 and May 2O17 were selected as drug-induced liver injury group,and 5O healthy volun-teers who received physical examination in our hospital during the same period were selected as normal control group. The liver transient ultrasonic elastography parameter Stiffness levels as well as serum liver fibrosis index and liver function index contents of two groups of subjects were detected. Pearson test was used to evaluate the correlation of Stiffness levels with liver fibrosis and liver function damage degree in patients with drug-induced liver injury. Results:Stiffness level in drug-induced liver injury group was higher than that in normal control group;serum liver fibrosis indexes HA,LN,CⅣ,PⅢNP and CG contents were higher than those of normal control group;serum liver function indexes ALT,AST,ALP,STB and γ-GT contents were high-er than those of normal control group. Conclusion:Transient ultrasonic elastography parameter Stiffness levels increase in pa-tients with drug-induced liver injury,and the specific levels are consistent with the liver fibrosis and liver function damage de-gree,and can be used as the objective means to evaluate the disease severity.%目的::探讨瞬时弹性超声技术对药物性肝损伤患者肝纤维化、肝功能的评估价值.方法::2O16年1月~2O17年5月间本院收治的药物性肝损伤患者68例作为药物性肝损伤组,同期在本院进行体检的健康志愿者5O例作为正常对照组.检测两组研究对象的肝脏瞬时弹性超声参数Stiffness水平,血清肝纤维化指标、肝功能指标含量.采用Pearson检验评估药物性肝损伤患者Stiffness水平与肝纤维化程度、肝功能损伤程度的相关关系.结果::药物性肝损伤组患者的Stiffness 水平高于正常对照组;血清中肝纤维化指标 HA、LN、CⅣ、PⅢNP、CG的含量高于正常对照组;血清中肝功能指标ALT、AST、ALP、STB、γ-GT的含量高于正常对照组.结论::药物性肝损伤患者瞬时弹性超声参数Stiffness水平增加,且具体水平与患者肝纤维化、肝功能损伤程度一致,可作为疾病严重程度评估的客观手段.