术前多西他赛联合S-1化疗对进展期胃癌病灶内癌基因表达的影响

摘要

Objective:To study the effect of the preoperative docetaxel combined with Tegafur Gimeracil Oteracil Potas-sium(S-1)chemotherapy on the oncogene expression in advanced gastric cancer lesion.Methods:Patients who were diagnosed with advanced gastric cancer in Yidu the First People's Hospital between April 2O14 and January 2O17 were selected as the re-search subjects and randomly divided into two groups,the DS group received preoperative docetaxel combined with S-1 neoad-juvant chemotherapy,and the control group accepted routine preoperative intervention.Surgically removed gastric cancer speci-mens were collected to determine the mRNA expression of tumor suppressor genes,proto-oncogene and invasion genes.Re-sults:ING5,p16,Noxa and Bax mRNA expression in gastric cancer lesions of DS group were significantly higher than those of control group while PTP1B,CDC25B,UHRF1,HOXB7,c-myc,GOLPH3,Vav2,ELMO,ZEB1 and Rho-A mRNA expres-sion were significantly lower than those of control group.Conclusion:Preoperative docetaxel combined with S-1 chemotherapy for advanced gastric cancer can increase the expression of tumor suppressor genes and inhibit the expression of proto-oncogene and aggression genes.%目的:研究术前多西他赛联合替吉奥(S-1)化疗对进展期胃癌病灶内癌基因表达的影响.方法:选择2O14年4月~2O17年1月在宜都市第一人民医院诊断为进展期胃癌的患者作为研究对象并随机分为两组,DS组接受术前多西他赛联合S-1新辅助化疗,对照组接受常规术前干预.取手术切除的胃癌标本并测定抑癌基因、原癌基因、侵袭基因的 mRNA 表达量.结果:DS组患者胃癌病灶内ING5、p16、Noxa、Bax的 mRNA 表达量显著高于对照组,PTP1B、CDC25B、UHRF1、HOXB7、c-myc、GOL-PH3、Vav2、ELM O、ZEB1、Rho-A的mRNA表达量显著低于对照组.结论:术前多西他赛联合S-1化疗用于进展期胃癌的治疗能够增加抑癌基因表达并抑制原癌基因、侵袭基因的表达.