过敏性紫癜患儿幽门螺旋杆菌感染影响肾功能、免疫应答的临床研究

摘要

目的:研究过敏性紫癜患儿幽门螺旋杆菌感染对肾功能、免疫应答的影响.方法:选择在中山市陈星海医院和惠州第三人民医院诊断为过敏性紫癜的患儿并根据幽门螺旋杆菌感染情况分为Hp(+)和Hp(-)HSP患儿,测定肾功能及免疫应答.结果:Hp(+)HSP患儿血清中Scr、BUN、CysC、TM、vWF、sVCAM-1、CTGF、MMP9、IL-17、IL-23的含量以及外周血中Th17细胞的含量显著高于Hp(-)HSP患儿,Hp(+)HSP患儿外周血中Treg细胞的含量及血清中TGF-β1、IL-10的含量显著低于Hp(-)HSP患儿,Hp(+)HSP患儿外周血单个核细胞中SOCS1、Tim1的mRNA表达量显著高于Hp(-)HSP患儿,SOCS3、Tim3的mRNA表达量与Hp(-)HSP患儿无显著性差异.结论:过敏性紫癜患儿幽门螺旋杆菌感染会加重肾功能损伤及自身免疫应答紊乱.%Objective: To study the effect of Helicobacter pylori infection on renal function and immune response in children with Henoch-Schoenlein purpura (HSP).Methods: Children diagnosed with Henoch-Schoenlein purpura in Zhognshan Chenxinghai Hospital and Huizhou Third People's Hospital between May 2013 and July 2016 were selected and divided into Hp (+) and Hp (-) HSP group according to Helicobacter pylori infection condition.Then renal function and immune response were determined.Results: Scr, BUN, CysC, TM, vWF, sVCAM-1, CTGF, MMP9, IL-17 and IL-23 contents in serum as well as Th17 cell content in peripheral blood of Hp (+) HSP group were significantly higher than those of Hp (-) HSP group, Treg cell content in peripheral blood as well as TGF-β1 and IL-10 contents in serum of Hp (+) HSP group were significantly lower than those of Hp (-) HSP group, SOCS1 and Tim1 mRNA expression in peripheral blood mononuclear cells of Hp (+) HSP group were significantly higher than those of Hp (-) HSP group, and SOCS3 and Tim3 mRNA expression were not significantly different from those of Hp (-) HSP group.Conclusion: Helicobacter pylori infection in children with Henoch-Schoenlein purpura can aggravate the damage of renal function and the disorder of autoimmune response.