腹腔镜手术治疗卵巢良性肿瘤的临床效果及对患者血清生殖激素、炎性因子、免疫功能和神经内分泌激素水平的影响

摘要

Objective: To investigate clinical effects of laparoscopic surgery on treating ovarian benign tumor and explicit influences of it on serum reproductive hormones, inflammatory factors, immune functions and neuroendocrine hormone levels in postoperative patients.Methods: A total of 116 cases of patients with ovarian benign tumor were selected and randomly divided as 58 cases of the control group and the observation group.For control group, open surgery therapy was provided, for observation group, laparoscopic surgery therapy was given.Situation of these two therapeutic operations and variations of serum reproductive hormones (E2, FSH, LH), inflammatory factors (CRP, TNF-α, IL-6), immune functions (CD3+, CD4+, CD8+, CD4+/CD8+), neuroendocrine hormones (COR, β-endorphin, glucagon) levels were compared.Results: After operation, E2 levels in observation group were significantly lower than control group, FSH, LH were significantly higher than control group, differences between the two groups were significant (P<0.05).Biochemical indexes on 1d, 3d after operation and CRP, TNF-α, IL-6, CD8+, COR, β-endorphin, glucagon levels in observation group were lower than control group, significant differences showed between groups (P<0.05);CD3+, CD4+, CD4+/CD8+ levels in observation group were significantly increased comparing with control group, differences were significant with statistical significance (P<0.05).Conclusion: Effects of laparoscopic surgery on treating ovarian benign tumor were significant.The surgery could effectively improve ovarian functions for patients with less damage on body immune system, it could effectively diminish suppression of immune function and release stress response.%目的:探讨腹腔镜手术治疗卵巢良性肿瘤的临床效果,明确其对术后患者血清血清生殖激素、炎性因子、免疫功能及神经内分泌激素水平的影响.方法:选取卵巢良性肿瘤患者116例,依据随机数据表法将其分为对照组和观察组各58例.对照组行开腹手术治疗,观察组行腹腔镜手术治疗,比较两种治疗手术情况、术前及术后血清生殖激素(E2、FSH、LH)、炎性因子(CRP、TNF-α、IL-6)、免疫功能(CD3+、CD4+、CD8+、CD4+/CD8+)、神经内分泌激素(COR、β-内啡肽、胰高血糖素)水平变化.结果:观察组术后E2水平较对照组明显低,FSH、LH较对照组明显高,组间比较差异显著(P<0.05).术后第1 d、3 d生化指标比较,观察组 CRP、TNF-α、IL-6、CD8+、COR、β-内啡肽、胰高血糖素水平比较,其水平均较对照组低,组间比较差异显著(P<0.05);观察组CD3+、CD4+、CD4+/CD8+水平,较对照组显著升高,差异较显著(P<0.05).结论:腹腔镜手术治疗卵巢良性肿瘤效果显著,可有效改善患者卵巢功能,对机体免疫系统损伤小,有效降低免疫功能抑制,缓解应激反应.