子痫前期患者血清sCD40及其配体含量与肾功能损伤的相关性研究

摘要

Objective: To study the correlation of serum sCD40 and its ligand contents with renal injury in patients with preeclampsia.Methods: A total of 68 patients with preeclampsia who were treated in our hospital between May 2012 and January 2016 were collected and divided into mild preeclampsia group (n=38) and severe preeclampsia group (n=30), and 57 health pregnant women who received antenatal care in our hospital during the same period were selected as control group.ELISA was used to detect serum contents of soluble CD40 (sCD40) and its ligand (sCD40L) as well as renal injury indexes;automatic biochemical analyzer was used to test the contents of renal function indexes;color Doppler diasonograph was used to detect renal aortal hemodynamic parameters.Results: Serum sCD40, sCD40L, BUN, β2-MG, Scr and Cys C contents as well as urine KIM-1 and NGAL contents of severe preeclampsia group and mild preeclampsia group were significantly higher than those of control group, and serum sCD40, sCD40L, BUN, β2-MG, Scr and Cys C contents as well as urine KIM-1 and NGAL contents of severe preeclampsia group were significantly higher than those of mild preeclampsia group;AT and RI levels of severe preeclampsia group and mild preeclampsia group were higher than those of control group while Vs and Vd levels were lower than those of control group, and the AT and RI levels of severe preeclampsia group were higher than those of mild preeclampsia group while Vs and Vd levels were lower than those of mild preeclampsia group;serum sCD40 and sCD40L contents in patients with preeclampsia were correlated with the renal injury severity.Conclusions: Serum sCD40 and sCD40L contents significantly increase in patients with preeclampsia, are correlated with patients' renal injury, and can be used to evaluate the degree of renal injury.%目的:探讨子痫前期患者血清sCD40及其配体含量与肾功能损伤的相关性.方法:收集本院收治的子痫前期患者68例,分为轻度子痫前期组38例、重度子痫前期组30例,另取同期在本院进行产检的健康孕妇57例作为对照组.采用ELISA检测血清可溶性CD40(sCD40)及其配体(sCD40L)以及肾损伤指标的含量;采用全自动生化分析仪检测肾功能指标的含量;采用彩色多普勒超声仪检测肾主动脉血流动力学参数.结果:重度子痫前期组、轻度子痫前期组血清中sCD40、sCD40L、BUN、β2-MG、Scr、Cys C的含量以及尿液中KIM-1、NGAL的含量均显著高于对照组且重度子痫前期组血清中sCD40、sCD40L、BUN、β2-MG、Scr、Cys C的含量以及尿液中KIM-1、NGAL的含量均显著高于轻度子痫前期组;重度子痫前期组、轻度子痫前期组AT、RI水平高于对照组,Vs、Vd水平低于对照组且重度子痫前期组AT、RI水平高于轻度子痫前期组,Vs、Vd水平低于轻度子痫前期组;子痫前期患者血清sCD40、sCD40L含量与肾功能损伤严重程度具有相关关系.结论:子痫前期患者血清中sCD40、sCD40L含量显著升高且与患者肾功能损伤程度具有相关关系,能够用于肾损害程度的评估.