血清Fractalkine对COPD合并肺心病患者血管重塑、氧化应激反应活化的影响

摘要

目的:研究血清Fractalkine对COPD合并肺心病患者血管重塑、氧化应激反应活化的影响.方法:选择因COPD在武警重庆总队医院住院治疗的患者,将单纯COPD患者纳入COPD组、COPD合并肺心病患者纳入COPD+PHD组;选择同期体检的健康志愿者作为研究的对照组.采集血清并测定Fractalkine、血管重塑指标、氧化应激指标的含量.结果:COPD+ PHD组、COPD组患者血清中Frac-talkine、ANG-2、MMP2、MMP9、VEGF、FGF2、Nogo-B、ET-1、MDA 的含量均高于对照组,T-AOC的含量低于对照组;COPD+PHD组患者血清中Fractalkine、ANG-2、MMP2、MMP9、VEGF、FGF2、No-go-B、ET-1、MDA 的含量均高于 COPD 组,T-AOC 的含量低于 COPD 组.Fractalkine 高含量的COPD+PHD患者血清中 ANG-2、MMP2、MMP9、VEGF、FGF2、Nogo-B、ET-1、MDA 的含量显著高于Fractalkine低含量的COPD+ PHD患者,T-AOC的含量低于Fractalkine低含量的COPD+ PHD患者.结论:COPD合并肺心病患者血清Fractalkine含量的升高能够加重血管重塑、促进氧化应激反应活化.%Objective:To study the effects of serum on vascular remodeling and oxidative stress activation in patients with COPD complicated by pulmonary heart disease.Methods:Patients who were hospitalized in Chongqing Armed Corps Po-lice Hospital due to COPD between June 2014 and April 2017 were selected,the patients with COPD alone were included in COPD group,and the patients with COPD complicated by pulmonary heart disease were included in COPD + PHD group;healthy volunteers who underwent physical examination during the same period were selected as the control group of the study. The serum was collected to determine the contents of Fractalkine,vascular remodeling indexes and oxidative stress indexes.Re-sults:Serum Fractalkine,ANG-2,MMP2,MMP9,VEGF,FGF2,Nogo-B,ET-1 and MDA contents of COPD+ PHD group and COPD group were higher than those of control group whereas T-AOC contents were lower than that of control group;ser-um Fractalkine,ANG-2,MMP2,MMP9,VEGF,FGF2,Nogo-B,ET-1 and MDA contents of COPD + PHD group were higher than those of COPD group whereas T-AOC content was lower than that of COPD group.Serum ANG-2,MMP2, MMP9,VEGF,FGF2,Nogo-B,ET-1 and MDA contents of COPD+ PHD group of patients with high Fractalkine content were significantly higher than those of COPD+ PHD group of patients with low Fractalkine content whereas T-AOC content was lower than that of COPD+PHD group of patients with low Fractalkine content.Conclusion:The increase of serum Fracta-lkine in patients with COPD complicated by pulmonary heart disease can aggravate the vascular remodeling and promote the ox-idative stress activation.