小剂量阿司匹林与丹参注射液配伍对妊娠高血压患者血液流变学、血管内皮功能及氧化应激水平的影响

摘要

Objective:To investigate tbe effect of low dose aspirin and salvia miltiorrbiza injection on bemorrbeology, endotbelial function and oxidative stress in patients witb pregnancy induced bypertension.Methods:A total of 180 pregnancy-induced bypertension patients treated in our bospital from April 2015 to November 2016 were selected as study subjects and randomly divided into control group and observation group witb 90 cases in eacb group.Tbe control group was given routine treatment.Tbe observation group was treated witb low-dose aspirin plus Salvia miltiorrbiza in tbe control group.After treat-ment,blood rbeology,vascular endotbelial function and oxidative stress were measured in two groups.Results:Tbe levels of MAP and 24 b Upro in botb groups were significantly lower tban tbose before treatment(P< 0.05).After treatment,tbe MAP and 24 b Upro levels in tbe observation group were significantly lower tban tbose in tbe control group(P<0.05).After treatment,tbe level of PT was significantly bigber tban tbat before treatment(P<0.05),wbile tbe level of DD and Fg was significantly lower tban tbat before treatment(P<0.05).Comparing tbe two groups after treatment sbowed tbat tbe PT level (P<0.05),and tbe levels of DD and Fg were significantly lower tban tbose in tbe control group(P<0.05);After treatment, NO levels in botb groups were significantly bigber tban tbose before treatment,ET-1 and ET-1/NO levels were significantly lower tban before treatment(P<0.05),after treatment,ET-1,NO and ET Tbe NO level in tbe observation group was signif-icantly bigber tban tbat in tbe control group(P<0.05),wbile ET-1 and ET-1/NO levels were significantly lower tban tbose in tbe control group(P<0.05);Compared witb tbose before treatment,tbe levels of SOD in tbe two groups were significantly increased(P<0.05)and MDA significantly decreased after treatment(P<0.05).Tbe SOD and MDA levels in tbe two groups after treatment sbowed tbat tbe SOD level in tbe observation group was significantly bigber tban tbat in tbe control group(P<0.05),wbile MDA level was significantly lower tban tbat of tbe control group(P<0.05).Conclusion:Tbe combination of low-dose aspirin and Salvia miltiorrbiza injection bas significant tberapeutic effect on gestational bypertension,and can effectively improve tbe bemorbeological parameters and endotbelial function of patients and reduce tbe oxidative stress injury in patients.It is wortb furtber clinical promotion.%目的:探讨小剂量阿司匹林与丹参注射液配伍对妊娠高血压患者血液流变学、血管内皮功能及氧化应激水平的影响.方法:选取在我院进行治疗的妊娠高血压患者180例为研究对象,随机分为对照组和观察组,每组90例.对照组给予常规治疗,观察组在对照组的基础上给予小剂量阿司匹林联合丹参注射液治疗,之后对两组患者血液流变学、血管内皮功能及氧化应激指标进行检测.结果:治疗后,两组M A P及24 b U pro水平较治疗前均明显降低(P<0.05),且治疗后比较观察组M A P及24 b U pro水平显著低于对照组(P<0.05);治疗后,PT 水平较治疗前明显升高(P<0.05),而D-D及Fg 水平则较治疗前明显降低(P<0.05),对两组治疗后进行组间比较发现,观察组PT 水平明显高于对照组(P<0.05),D-D及Fg水平均则明显低于对照组(P<0.05);治疗后,两组N O水平较治疗前显著升高,ET-1和ET-1/NO水平则较治疗前明显降低(P<0.05),对两组治疗后ET-1、NO及ET-1/NO水平比较之后发现,观察组NO水平明显高于对照组(P<0.05),而ET-1和ET-1/NO水平则明显低于对照组(P<0.05);与治疗前相比,治疗后两组SOD明显升高(P<0.05),M DA明显降低(P<0.05),对两组治疗之后SOD及MDA水平分析发现,观察组SOD水平较对照组显著增加(P<0.05),而MDA 水平则较对照组显著降低(P<0.05).结论:小剂量阿司匹林与丹参注射液配伍治疗妊娠期高血压能有效改善患者血液流变学指标及血管内皮功能,降低患者氧化应激损伤,值得临床进一步推广.