营养干预联合小剂量阿司匹林对子痫前期患者肾功能、内皮损伤及胎盘缺氧的影响

摘要

Objective:To explore the effects of nutrition intervention combined with small-dose aspirin on renal func-tion,endothelial injury and placental hypoxia in patients with preeclampsia.Methods:90 patients with preeclampsia who were treated and gave birth in Zigong Maternal and Child Health Hospital between December 2015 and January 2017 were selected as the research subjects and divided into control group(n=45)and nutrition intervention group(n=45)by random number table method.The differences in renal function,endothelial injury and placental hypoxia were compared between the two groups.Re-sults:After treatment,renal function indexes Scr,BUN and 24hPro levels of nutrition intervention group were lower than those of control group;endothelial injury indexes ET-1 and PTX3 contents were lower than those of control group whereas APN and ADM contents were higher than those of control group;apoptosis molecules Fas,Bax,Caspase-3 and Caspase-8 mR-NA expression in placental tissue were lower than those of control group whereas Bcl-2 mRNA expression was higher than that of control group.Conclusion:Nutrition intervention combined with small-dose aspirin therapy can effectively optimize renal function,relieve endothelial injury,inhibit placenta hypoxia and reduce placental trophoblast apoptosis in patients with pre-eclampsia.%目的:探讨营养干预联合小剂量阿司匹林对子痫前期患者肾功能、内皮损伤及胎盘缺氧的影响.方法:选择在自贡市妇幼保健院进行治疗及分娩的子痫前期患者90例作为研究对象,参照随机数表法分为对照组、营养干预组各45例.对比两组患者肾功能及内皮损伤程度、胎盘缺氧程度的差异.结果:治疗后,营养干预组肾功能指标Scr、BUN、24 hPro 的水平低于对照组;内皮损伤指标ET-1、PTX3的含量低于对照组,A PN、ADM 的含量高于对照组;胎盘组织中凋亡分子Fas、Bax、Caspase-3、Caspase-8 m RNA的表达量低于对照组,Bcl-2 m RN A的表达量高于对照组.结论:子痫前期患者接受营养干预联合小剂量阿司匹林治疗,可有效优化肾功能并减轻内皮损伤,抑制胎盘缺氧、减少胎盘滋养细胞凋亡.