目的:观察胃苏颗粒联合三联疗法(埃索美拉唑、替硝唑和阿莫西林)对慢性胃炎患者胃黏膜环氧化酶-2(COX-2)、钙黏蛋白E(E-cadherin)及血清降钙素原(PCT)、胃泌素水平的影响.方法:将90例慢性胃炎患者按抽签法随机分为对照组(n=45)和观察组(n=45),两组均行常规治疗.在此基础上,对照组行三联疗法治疗,观察组给予三联疗法联合胃苏颗粒治疗.观察所有受试者治疗前后COX-2、E-cadherin、PCT及胃泌素表达情况.结果:治疗前,两组胃黏膜COX-2和E-cadherin表达水平差异无统计学意义(P>00.5);治疗后,两组COX-2和E-cadherin水平较组内治疗前均显著降低,差异有统计学意义(P<00.5),且观察组低于治疗后对照组,比较差异有统计学意义(P<00.5).治疗前,两组血清PCT和胃泌素水平比较,差异无统计学意义(P>00.5);治疗后,两组PCT和胃泌素水平较组内治疗前均显著降低,差异有统计学意义(P<00.5),且观察组低于治疗后对照组,比较差异有统计学意义(P<00.5).结论:胃苏颗粒联合三联疗法治疗慢性胃炎,能有效降低COX-2、E-cadherin、PCT和胃泌素水平,缓解机体胃黏膜损伤,减轻反应症状,是临床有效的治疗方案.%Objective:To observe the effects of Weisu Granule combined with triple therapy (esomeprazole ,tinidazole and amoxicillin) on gastric mucosal cyclooxygenase-2 (COX-2) and cadherin E (E-cadherin) ,serum procalcitonin (PCT ) and gastrin in patients with chronic gastritis .Methods:Results:There was no significant difference in the levels of gastric mucosal COX-2 and E-cadherin between the two groups before treatment (P>00.5) .After treatment ,the levels of COX-2 and E-cad-herin in both groups were significantly lower than those before treatment (P<0 .05) .And the observation group was lower than the control group after treatment (P<00.5) .There was no significant difference in serum PCT and gastrin levels between the two groups before treatment (P>00.5) .After treatment ,the levels of PCT and gastrin in both groups were significantly lower than those before treatment (P<00.5) .And the observation group was lower than the control group after treatment (P<00.5) .Conclusions:Wei Su granule combined with triple therapy in the treatment of chronic gastritis ,can effectively reduce the levels of COX-2 ,E-cadherin ,PCT and gastrin ,relieve the gastric mucosal injury and symptoms ,which is a clinically effec-tive treatment .
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