miR-518b在稽留流产患者绒毛组织及血清中的表达及其意义

摘要

Objective:To investigate the expression of microRNA518b (miR-518b) in villous tissues and serum of patients with missed abortion and its clinical significance.Methods:Villous tissues and serum samples from 30 cases of missed abortion and 30 cases of early pregnancy abortion were collected.The expression of miR-518b was determined by real-time fluorescent quantitative PCR (qPCR).Results:The expression level of miR-518b in villous tissues and serum of patients with missed abortion was significantly increased,compared with the controls (P＜0.01).Conclusion:Upregulation of miR-518b expression in villous tissues and serum might be associated with the occurrence of missed abortion.%目的:探讨稽留流产患者绒毛组织及血清中miR-518b的表达及其意义.方法:应用实时荧光定量PCR (qPCR)方法检测30例稽留流产患者(观察组)及30例早孕人工流产患者(对照组)绒毛组织及血清中miR-518的表达量.结果:观察组患者绒毛组织及血清中miR-518b的表达量均明显高于对照组(P＜0.01).结论:miR-518b在稽留流产患者绒毛及血清中的表达升高,可能与稽留流产的发病相关.