综合干预对普外科围手术期抗菌药物预防性使用的效果分析

摘要

Objective To evaluate the effect of antibiotics during perioperative period through comprehensive interventions,so as to provide the basis for reasonable use of antibiotics. Methods The comprehensive intervening measure and the retrospective investigation was adopted to study the prophylactic application of antibiotics in three type I incision operation such as thyroid ,breast and abdominal external hernia. Results The utilization ratio of antibiotics dropped from 94.68%of preintervention periods to 62.84%and 5.26%of post-intervention1,2 periods. The difference has statistical significance(P<0.01).In addition, the rational rates of the medicine timing, the select of antibiotics and the treatment duration were all have notable increase(P<0.05). Conclusions The comprehensive intervention in the prophylactic use of antibiotics during perioperative period are both necessary and practical.It was worth popularizing.%目的：评价综合干预措施实施效果，为规范临床合理使用抗菌药物提供依据。方法采取临床药师下临床、专业知识培训、对患者进行用药宣传教育等技术手段与将抗菌药物临床应用情况纳入考核体系等行政干预监督管理等相结合的综合干预措施，对围术期抗菌药物预防性使用进行干预，采用回顾性调查的方法，对干预前后普外科出院的甲状腺手术、乳腺手术和腹外疝修补术3种I类切口手术患者围术期抗菌药物预防性使用情况进行分析评价。结果患者围术期抗菌药物使用率由干预前的94.68%，下降为干预后第1阶段的62.84%，第2阶段的5.26%，差异有统计学意义（P<0.01）。此外术前给药时机、药物选择、用药疗程等指标合理率均显著提高（P<0.05）。结论综合干预措施是加强普外科围术期抗菌药物预防性使用管理的一套有效方法，值得推广。