新疆35例胃间质瘤临床病理及预后分析

摘要

Objective Discussion on Xinjiang in 35 cases of gastric gastrointestinal stromal tumor clinical pathological diagnosis, treatment and prognosis.Methods We retrospectively analyzed 35 cases from 2006 January to 2010 December in the stomach of the Xinjiang Uygur Autonomous Region people's Hospital of gastrointestinal stromal tumor in patients with clinical and pathological data. Results According to the Fletcher risk classification, 4 cases of very low risk, low risk in 8 cases, 15 cases in 8 cases of high risk, risk. CDll7, CD34, SMA, S-100 protein positive expression rates were 94.3%, 88.6%, 34.3%, 25.8%, independent of their positive expression rate and tumor risk degree (P>0.05).Whether the tumor infiltrating the muscularis mucosa or serosal layer and tumor risk degree of correlation (P<0.05).In the high risk degree, the recurrence rate of 25%, significantly higher than the very low and low risk (P<0.001). Conclusions Fletcher classification of gastrointestinal stromal tumor grading evaluation more scientific and reasonable.Tumor infiltrating the muscularis mucosa and serosa layer is an important indicator of tumor risk.The results indicated that oral imatinib mesylate can improve the prognosis of patients.%目的:探讨新疆35例胃间质瘤的临床病理特点及影响预后的因素.方法:回顾性总结2006年1月至2010年12月新疆维吾尔自治区人民医院收治的35例胃间质瘤患者的临床和病理资料.结果:根据Fletcher风险分级,极低风险4例,低风险8例,中风险15例,高风险8例.C D l l7、C D34、S M A、S-100蛋白阳性表达率分别为94.3%、88.6%、34.3%、25.8%,其阳性表达率与肿瘤危险程度无关(P>0.05).肿瘤是否浸润黏膜肌层或浆膜层与肿瘤危险程度相关(P<0.05).中、高风险程度者复发率25.0%,明显高于极低和低风险者(P