炎症小体在血栓性疾病发病中的作用研究进展

摘要

炎症小体是位于胞浆内的一组多蛋白复合体,其活化可诱导促炎性细胞因子IL-1β和IL-18的成熟与释放,在早期动脉粥样硬化中起促进作用.近年来发现血栓性疾病中炎症小体被激活,且活化后炎症小体及其活化诱导产生的细胞因子促进血栓性疾病的发生、发展且不利于预后.随着对血栓性疾病发生发展机制的研究,炎症小体与血栓性疾病的关系逐渐成为研究的重点.最近关于炎症小体与血栓性疾病的关系的研究日益增多,本文就炎症小体与血栓性疾病的关系及其研究最新进展作一综述.%Inflammasome is a group of polyprotein complexes located in the cytoplasm,its activation can induce the maturation and release of proinflammatory cytokines IL-1β3 and IL-18,and promote the early atherosclerosis.In the recent years,it is found that the inflammasome is activated in thrombotic deseases,moveover,the activated inflammasome and its activation induced cytokines promote the occurrence and development of thrombolic deseases,and show the unfavaourable effect on prognosis.With further exploration on the mechanisms of thrombotic diseases,the relationship between the inflammasome and thrombotic diseases increasingly become a hot spot of research.This review focuses on the action mechanisms of inflammasome in thrombotic diseases.