中国人群HLA-B基因多态性与HIV关联性的Meta分析

摘要

Objective To evaluate the association between gene of HLA-B and HIV infection and disease progression in Chinese population. Methods Electronic searches were conducted roundly to find the case-control studies and cross-sectional studies on the association between HLA-B gene polymorphism and HIV infection or disease course. References of relevant studies were also retrieved. The references was screened with the inclusion and exclusion criteria, and then data were extracted and methodological quality of the studies was judged. Statistical analysis was carried out with RevMan 4.2 and SAS 9.1.3. Results 11 studies were included lastly. 6 studies were about the association between gene of HLA-B and disease progression in Chinese HIV infected population , meta-analysis results revealed that the pooled OR of HLA-B*27, HLA-B*51, and HLA-B*58 were 0.49, 0.61 and 0.65 respectively, and they acted as the protective genes in the HIV/AIDS progression. HLA-B*35(pooled OR=1.87) was the risk gene in the HIV/AIDS progression. 5 studies were about the association between gene of HLA-B and HIV infection in Chinese population, meta-analysis results revealed that the pooled OR of HLA-B*37 and HLA-B*46 were 1.62 and 1.19, and they acted as the susceptible genes in HIV infection. HLA-B*39(pooled OR=0.67) was the protective gene in HIV infection. Conclusions HLA-B*27, HLA-B*51 and HLA-B*58 may act as the protective genes in HIV infected disease progression , and HLA-B*35 may act as the susceptible gene in HIV infected disease progression;HLA-B*39 may act as the protective gene in HIV infection. HLA-B*37 and HLA-B*46 may act as the susceptible genes in HIV infection.%目的：系统评价中国人群HLA-B 基因多态性与HIV 易感性及疾病进程的关系。方法全面检索查找已发表的相关病例对照研究及横断面研究，并追溯其参考文献，按纳入和排除标准进行文献筛选、资料提取及质量评价，使用RevMan 4．2及SAS 9．1．3软件进行统计分析。结果共纳入11篇文献。6篇为HLA-B基因与HIV疾病进程相关性研究，Meta 分析结果显示，HLA-B*27、HLA-B*51和HLA-B*58为HIV/AIDS 病程进展的保护性基因，合并比值比分别为0．49、0．61和0．65。 HLA-B*35为HIV/AIDS 病程进展的危险基因，合并比值比为1．87。5篇为HLA-B基因与HIV易感性的关联性研究，Meta分析结果显示，HLA-B*37和HLA-B*46为HIV感染的易感性基因，合并比值比分别为1．62和1．19。 HLA-B*39为 HIV 感染保护性基因，合并比值比为0．67。结论 HLA-B*27、HLA-B*51和HLA-B*58可能延缓而 HLA-B*35可能加速中国人群 HIV 感染后的疾病进程；HLA-B*39可能降低而HLA-B*37和HLA-B*46可能增高中国人群对HIV感染的易感性。