To make clear if parkinson disease(PD) has cortical latency of transcranial magnetic stimulation(TMS)-motor evoked potential(MEP) abnormality and cortical latency(Lat) changes with the developing state of illness. Methods:Rats were randomly assigned into PD model group(n=26) and the control group(n=14). The operated target was the right substaniia nigra pars compaeta(SNc) and right ventra tegmental area(VTA) > which were injected with 2 μL(4 μg /μL 6-OHDA in PBS) solution of 6-OHDA in PD model group. Saline containing 2% vitamin C with isometry injected to the same location in the control group. Lat was examined before operation,and a week and three weeks after operation. Statistical analysis was performed by SPSS 11. 5 software. Results: A week after operation, Lat of left lower limb was significantly low in the PD model group (P<0. 05) as compared with the control group. In the PD model group,Lat of left lower limb significantly lower than right ones(P<0. 05). Three weeks after operation,Lat of left lower limb was significantly low in the PD model group(P<0. 05) as compared with the control group. And Lat of left lower limb significantly lower than right ones(P< 0. 01). Conclusion: The cortex excitability increased. The worse the PD model state is the longer the course of disease PD model rats and the more obviously the cortical Lat is shortened.%目的:通过对帕金森病(PD)模型大鼠经颅磁刺激(TMS)运动诱发电位(MEP)皮层潜伏期(Lat)的测值以了解其随病情发展的变化情况.方法:健康雄性(SD)大鼠40只,随机分为2组:①PD模型组26只,②对照组(生理盐水组)14只.选取右侧黑质致密部(substantia nigra pars compacta,SNc)与中脑腹侧背盖(ventra tegmental area,VTA)为手术靶点,PD模型组注射6-羟基多巴胺(6-OHDA)制备PD动物模型,对照组注射同等体积的生理盐水.于注射前、注射后第1周、第3周末分别行双下肢TMS-MEP检查.结果:术后1周,PD组鼠左下肢Lat较对照组缩短(P＜0.05),PD组自身左右侧TMS- MEP比较,左下肢Lat较右下肢缩短(P＜0.05)；术前、术后第1周末、术后第3周末PD组大鼠左下肢Lat进行性缩短(P＜0.01),PD组大鼠右下肢及对照组大鼠左侧及右侧下肢Lat皆无显著变化(P＞0.05).结论:PD模型大鼠损毁侧皮层兴奋性增加,且与症状严重程度有关.PD模型大鼠病情越重、病程越长,Lat缩短越明显.
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