目的 观察补肾中药复方首参颗粒对颈动脉粥样硬化患者的临床疗效.方法 将80例患者随机分为两组,对照组口服普伐他汀,治疗组服用首参颗粒,疗程均为6个月.于治疗前后采用彩色多普勒超声检测颈动脉硬化患者颈动脉内膜-中层厚度(IMT),动脉硬化仪检测肱踝脉搏波传导速度(baPWV),并观察用药前后患者的血脂变化及肝、肾功等安全性指标.结果 治疗后6个月,对照组IMT、TC、TG、LDL-C及TC/HDL-C比值较治疗前均明显降低,HDL-C较治疗前明显升高；治疗组baPWV较治疗前明显降低,TG、TC/HDL-C比值较治疗前降低,HDL-C较治疗前明显升高.结论 首参颗粒可通过降低IMT、baPWV及改善脂质代谢进而有效干预治疗颈动脉粥样硬化病变.%Objective: To observe the clinical curative effect of compound Chinese medicine for reinforcing kidney shoushen granules on carotid atherosclerosis in patients. Methods: 80 patients were randomly divided into two groups. The control group was treated with pravastatin,treatment group took shoushen granules,the treatment course is 6 months. Before and after the treatment with color Doppler ultrasound detection of carotid atherosclerosis in patients with carotid artery intima-media thickness (IMT), arteriosclerosis detection brachial ankle pulse wave velocity (baPWV) before and after treatment were observed,and the changes of blood lipid in patients with hepatic,renal function and safety index. Results: after 6 months of treatment,the control group IMT,TC,TG, LDL-C and TC/HDL-C ratio were significantly lower than that before treatment,HDL-C significantly increased; baPWV in treatment group was significantly lower than that before treatment,TG,TC/HDL-C were lower than those before therapy,HDL-C significantly increased. Conclusion: Shoushen granules can reduce the IMT,baPWV and improve lipid metabolism and effective intervention for the treatment of carotid atherosclerosis.
展开▼
