银杏叶制剂治疗缺血性中风急性期临床疗效的系统评价

摘要

目的 系统评价银杏叶制剂治疗缺血性中风急性期的临床疗效及安全性.方法 运用系统评价方法,检索银杏叶制剂治疗中风的随机对照试验,筛选合格研究,评价纳入研究质量,采用异质性检验、Meta分析等方法统计相关数据.结果 29项研究符合选择标准,采用随机效应模型统计,总有效率比较的RR(99％CI)、NNT(99％CI)、WMD(99％CI)Meta分析结果分别为1.20(1.13,1.28)、6.67( 5.27,9.09)、-3.75(-4.49,-3.01),银杏叶注射液头痛的PetoOR (99％CI)为7.90(1.24,50.31).结论 现有证据显示,银杏叶制剂有益于改善出血性中风急性期患者的神经功能缺损程度,其注射液临床疗效优于片剂；但银杏叶注射液存在提高缺血性中风急性期患者头痛的风险.%Objective: To evaluate efficacy and safety of ginkgo leaf preparation Tor acute ischaemic stroke. Methods: The eligible studies of randomized controlled trails (RCTs) of ginkgo leaf preparation for acute 18-chaemic stroke were identified. The methodological quality of inclusive trails was assessed by Jadad scale. Heterogeneity test,Meta-analysis,funnel plot analysis and sensitivity analysis were used to analyse data. Results: 29 RCTs were included. Meta -analysis indicated that relative risk of overall effective rate was 1.20 [99% CI (1.13,1.28)],NNT(99%CI) was 6.67(5.27,9.09). WMD (99%C1) of neural function defect score was -3.75(~ 4.49,-3.01) and Peto OR (99%CI) of headache was 7.90 (1.24,50.31). Conclusion: This systematic review shows that ginkgo leaf prearation is effective for acute ischaemic stroke. However,ginkgo leaf prearation in acute ischaemic stroke increases risk of headache.