泻火平肝汤对急性脑出血患者血清D-D、hs-CRP、 NSE、 TNF-α的影响

摘要

Objective:To evaluate the clinical efficacy and safety of Xiehuo Pinggan Decoction on acute intracerebral hemorrhage.Methods:60 patients with intracerebral hemorrhage (ICH),as the research objects,according to admission order,were randomly divided into the control group and the observation group,30 cases in each.The control group were given conventional Western medicine comprehensive treatment,while the observation group were given conventional Western medicine treatment and Xiehuo Pinggan Decoction.The neurological deficit scores (NIHSS),the daily living ability scale (Barthel index),the volume of hematoma and the changes of TCM symptom scores were observed before and after treatment,and the clinical efficacy and safety were evaluated.Resuits:Before treatment,there were no statistically significant differences in NIHSS score,Barthel index,hematoma volume and TCM symptom score between the 2 groups (P＞ 0.05).After treatment,the NIHSS score,hematoma volume and TCM symptom score of the 2 groups were significantly lower than before treatment (P＜ 0.05),and the observation group decreased more significantly (P ＜ 0.05);after treatment,the Barthel index of the 2 groups were improved (P＜ 0.05),and compared with the control group,the daily life ability of the observation group was improved more significantly (P＜ 0.05).Compared with the control group,the effective rate of the observation group was better than that of the control group in clinical efficacy and symptoms of traditional Chinese Medicine (P＜ 0.05).There was no serious adverse reaction in the course of treatment.Conclusion:Xiehuo Pinggan Decoction combined with Western medicine routine treatment on cerebral hemorrhage has high clinical value in imaging objective index,curative effect,symptom improvement,neurological impairment and activity score of daily living.%目的 观察泻火平肝汤对急性脑出血患者血清D-二聚体(D-D)、超敏C反应蛋白(hs-CRP)、神经源烯醇化酶(NSE)、肿瘤坏死因子-α(TNF-α)的影响.方法 选取脑出血患者60例为研究对象,按入院顺序编号,分配选取的随机数字,并对随机数字进行处理,分为对照组和观察组各30例.对照组给予西医常规综合治疗,观察组给予西医常规治疗上加服泻心平肝汤.观察治疗前、治疗7d、治疗14 d D-D、hs-CRP、NSE、TNF-α、血肿体积、神经功能缺损评分(NIHSS)情况,并评价临床疗效.结果 治疗前两组D-D、hs-CRP、NSE、TNF-α、血肿体积、NIHSS评分比较差异均无统计学意义(P＞0.05).治疗7d及14d,两组D-D、hs-CRP、NSE、TNF-α水平较治疗前显著下降(P＜0.05),治疗14d,血肿体积大小、NIHSS评分也较治疗前明显降低(P＜0.05),且观察组在各时间点上述指标较对照组降低更明显(P＜0.05).观察组总有效率90.00％,显著高于对照组的76.66％ (P＜0.05).结论 泻火平肝汤能降低脑出血患者D-D、hs-CRP、NSE、TNF-α水平,提高治疗疗效.