痔血合剂改善溃疡性结肠炎患者肠道出血的回顾性研究

摘要

目的 观察痔血合剂在活动期溃疡性结肠炎改善肠道出血缓解中的临床疗效并探讨其作用机制.方法 将80例溃疡性结肠炎伴有便血的患者运用随机数字表法分为两组,对照组予常规标准化治疗,治疗组在上述基础上用痔血合剂口服. 观察患者临床症状,结肠镜病理情况,便血改善程度以及血红蛋白(Hb)、红细胞计数(RBC)、血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、血浆凝血酶时间(TT)及血浆纤维蛋白原(FIB)等指标. 结果 治疗组显效率为92.50%,高于对照组的40.00%(P＜0.05);两组病例治疗后便血改善程度评分优于治疗前(P＜0.05),且治疗组优于对照组(P＜0.05);两组病例治疗后RBC、Hb、PLT高于治疗前(P＜0.05), 且治疗组高于对照组(P＜0.05);两组病例治疗后APTT、TT低于治疗前(P＜0.05),FIB高于治疗前(P＜0.05),且治疗组优于对照组(P＜0.05). PT两组治疗前后差异无统计学意义(P＞0.05).结论 对于溃疡性结肠炎肠道出血的患者,在常规治疗的基础上,辅以痔血合剂治疗,可以改善患者血清学指标,早期缓解出血症状,提高生活质量.%Objective: To explore the clinical curative effecacy of Zhixue Mixture on intestinal bleedinq in ac-tive ulcerative colitis,and to discuss the mechanism of its action. Methods: 80 patients with ulcerative colitis and hematochezia were randomly divided into the treatment qroup and the control qroup,with 40 cases in each qroup. The two qroups were treated with routine standardized treatment,and the treatment qroup was added oral Zhixue Mixture on the basis. The clinical symptoms,patholoqical condition of colonoscopy,hematochezia improvement and RBC,Hb,PLT,PT,APTT,TT and FIB were observed. Results: The effective rate of the treatment qroup was 92.50%,hiqher than that of the control qroup 40.00%(P＜0.05). After treatment,the improvement rate of hema-tochezia in the two qroups was better than that before treatment(P＜0.05),and the treatment qroup was better than the control qroup (P＜0.05). After treatment,RBC,Hb and PLT of the two qroups were hiqher than those before treatment (P＜0.05),and the treatment qroup was hiqher than the control qroup (P＜0.05). After treatment,the APTT and TT of the two qroups were lower than those before treatment(P＜0.05);FIB was hiqher than that before treatment(P＜0.05),and the treatment qroup was better than the control qroup(P＜0.05). There was no siqnificant difference in PT between the two qroups before and after treatment (P＞0.05). Conclusion: On the basis of rou-tine treatment,with the treatment of Zhixue Mixture,the patients with ulcerative colitis can improve the seroloqical index,relieve the bleedinq symptoms early and improve the quality of life.