目的 观察抗纤益心浓缩丸对大鼠下腔静脉血栓形成及凝血功能[部分活化凝血酶原时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)]的影响,探讨其治疗扩张型心肌病的部分作用机制.方法 将SD大鼠随机分为抗纤益心浓缩丸高剂量组(18.8 g/kg)、低剂量组(4.7 g/kg),华法林钠组(1.1 mg/kg),模型对照组(等容量生理盐水),各组动物于每日同一时间灌胃1次,连续灌胃7d.灌胃结束后进行深静脉血栓形成造模, 4 h后开腹腔,腹主动脉取血检测APTT、TT、PT含量,取下腔静脉血栓,称其湿质量,于60℃烘箱中烘24 h,称取干质量.结果 与模型对照组相比,抗纤益心浓缩丸高、低剂量组及华法林钠组均能明显减轻结扎大鼠下腔静脉所形成的血栓的干、湿质量(P<0.05),中药高剂量组和华法林钠组能显著延长APTT、PT、TT(P<0.05).结论 抗纤益心浓缩丸可明显减轻下腔静脉血栓干、湿质量,同时可延长APTT、PT、TT,具有一定的抗血栓作用.%Objective: To study the effects of Kangxian Yixin Concentrated Decoction on inferior vena cava thrombosis in rats and coagulation function APTT,PT and TT,and to investigate the mechanism of the treatment of dilated cardiomyopathy. Methods: SD rats were randomly divided into high doses group(18.8 g/kg),low dose group(4.7 g/kg),warfarin sodium group(1.1 mg/kg),and the normal control group(the equal amount of normal saline). The animals in each group were intragastric once a day at the same time for seven days. Animal model was made based on deep venous thrombosis after the end of the gavage. After 4 hours,abdominal cavity was opened and the blood was taken from the abdominal aorta to detect the content of APTT,TT and PT from the ab-dominal aorta. The inferior vena cava thrombus was taken out,and its wet weight was measured. Baked for 24 hours in a oven at 60 degrees centigrade,the dry weight was measured. Results: Compared with the normal con-trol group,there was an obvious reduce in the wet weight and dry weight of inferior vena cava thrombus in high doses group,low dose group and warfarin sodium group(P<0.05),and APTT,PT and TT was prolonged(P<0.05). Conclusion: Kangxian Yixin Concentrated Decoction can significantly reduce the wet weight and dry weight of the inferior vena cava thrombus,and prolong APTT,PT and TT,with antithrombotic effect.
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