目的 探讨老年朗格汉斯细胞组织细胞增生症患者的临床特征及治疗方法.方法 收集3例经病理学证实的老年朗格汉斯细胞组织细胞增生症患者的临床资料.本文3例老年患者均以淋巴结及内脏器官侵犯为主,无皮疹,1例低热.1例行化疗,1例行放化疗,1例行放疗；观察他们的临床特征,并根据RECIST标准评价治疗疗效、CTCAE v3.0进行安全性评估、观察总体生存期.结果 行放/化疗后患者的肿块缩小,生存期延长,最长26个月.主要副作用为放化疗后骨髓抑制.结论 老年朗格汉斯组织细胞增生症的患者,以淋巴结及内脏器官侵犯为主,放/化疗是一种较好的治疗选择.%Objective To investigate the clinical features and treatment of the elderly Langerhans cell histiocytosis patients. Methods We collected 3 elderly clinical data, which confirmed by pathology of Langerhans cell histiocytosis. The lesions mainly affected the lymph nodes and internal organs, no rash, and one case of low fever. One patient received chemotherapy, one patient received radiotherapy and chemotherapy, one patient radiotherapy. We observed their clinical features. We evaluated treatment efficacy according to the RECIST criteria, safety assessment by CTCAE v3.0,and observed the patients's overall survival. Results The mass reduced after radiotherapy /chemotherapy, overall survival longer, up to 26 months; the main side effect was bone marrow suppression after radiotherapy and chemotherapy. Conclusion The lesions mainly affected the lymph nodes and internal organs in the elderly Langerhans cell histiocytosis patients, radiotherapy/ chemotherapy maybe is a better treatment option to them.
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