瞬时弹性扫描检测慢性乙型肝炎患者肝纤维化的临床研究

摘要

Objective:To investigate clinical application of transient elastography (Fibroscan ) in patients with chronic hepatitis B (CHB). Methods; A total of 310 CHB patients including 23 patients with severe chronic liver failure(SCLF)and 65 patients with liver cirrhosis (LC) diagnosed by clinical manifestations were involved in the study. Liver stiffness (LS) was detected by Fibroscan device. HBV serum markers,HBV DNA level,alanine transaminase (ALT) and total billirubin (TBil) were also detected simultaneously. Results:CHB patients with LC showed significant higher LS than those without LC. Severe liver inflammation, such as SCLF, also with increased LS. Age and gender tended to affect LS. Conclusions; Fibroscan is an effective method for assessing liver fibrosis and diagnosing LC in patients with CHB. Some influential factors, such as liver inflammation,age and gender,should be taken into consideration when we analyze individual cases.%目的:研究肝脏瞬时弹性检测仪(Fibroscan)在慢性乙型肝炎患者中的应用.方法:收集诊断为慢性乙型肝炎患者310例,其中包括23例慢性重型肝炎及65例肝硬化患者,使用Fibroscan检测肝脏硬度值,同时检测乙肝标志物HBV DNA、丙氨酸氨基转移酶、总胆红素水平.结果:慢性乙肝肝硬化患者的肝脏硬度值显著高于非肝硬化患者.肝脏重度炎症如重型肝炎,也可导致肝脏硬度值增大.年龄和性别因素可能对肝脏硬度值有影响.结论:Fibfroscan是评价慢性乙肝患者肝脏纤维化程度和诊断肝硬化的有效方法.在对个体病例进行分析时,需要考虑年龄和性别、肝脏炎症因素对肝脏硬度值的影响.