高血压病患者颈动脉硬化与基质金属蛋白酶-3基因多态性的研究

摘要

目的 探讨原发性高血压病患者颈动脉硬化与基质金属蛋白酶-3(MMP-3)多态性的关系.方法 104例高血压病患者(高血压病组),健康体检者102例为对照组,MMP-3基因启动子-1171位点产生三种基因型:6A/6A、5A/6A、5A/5A,分析两组基因的分布差异；其中高血压组68例与对照组30例行颈动脉超声检查,观察其内-中膜厚度(IMT).结果 高血压病组MMP-3 6A/6A基因型和6A等位基因频率均高于对照组(基因型65.4％/53.9％,等位基因82.2％/76.0％),但分布差异无统计学意义(基因型P=0.094,等位基因P=0.120)；高血压病组6A/6A基因型者颈动脉分叉前处IMT大于5A/5A+5A/6A基因型者,差异有统计学意义(P＜0.05).结论 原发性高血压病患者颈动脉IMT与多种危险因素密切相关,高血压病组6A/6A基因型者颈动脉IMT较厚.%Objective To investigate the association between polymorphism of matrixmetalloproteinase 3 (MMP-3) and cartotid aterty of essential hypertension. Methods This studyt enrolled 104 patients with hypertension and 102 normal volunteers. After PCR procedure, the genotypes of MMP-3 were scored according to the patterns of DNA bands. The ultrasound examination was performed in 68 patients with hypertension and 30 normal volunteers to investigate the changes of intima-media thickness of carotid arteries. Results The frequency of MMP -3 6 A/6 A type and allele 6A were higher in the hypertension group than those in the control group(65.4%/53,9%, 82%/62%),but the difference was not statistical (gtype P=0.094, allele P=0.120). The IMT of patients with MMP-3 6A/6A gtype was significantly higher compared with that of patients in the control group (P<0.05). Conclusion The CCA-IMT is closely associated with many risk actors carotid IMT is higher among patients with 6 A/6 A gtype.