前列腺被膜支动脉阻力指数与前列腺特异性抗原密度在前列腺癌诊断中的价值

摘要

Objective To explore the value of resistance index ( RI) of capsular artery of prostate gland and prostate gland antigen density( PSAD) in diagnosis of prostate cancer. Methods One hundred and twenty-eight patients with prostate disease confirmed by prostate area 10-point method under transrectal ultrasound guidance, postive lesion histological biopsy and pathology were enrolled in this study, including 63 cases of piostatic cancer (pro static cancer group) and 65 cases of benign prostate hyperplasia ( control group) . The RI of capsular artery of prostate gland, volume of prostate gland were detected by transrectal ultrasound and total prostate specific antigen( TPSA) was measured , the PSAD was calcuated, then the sensitivity, specificity and accuracy of RI and PSAD in diagnosis of piostatic cancer were analyzed. Results RI of capsular artery and PSAD in piostatic cancer group were higher than those in control group, there was significant difference between two groups(P0. 30 ng/(ml - cm') in diagnosis of piostatic cancer were 88. 89% , 70. 77% , and 79. 69% , respectively. Conclusion RI of capsular artery of prostate gland and PSAD are reliable index in diagnosis of piostatic cancer.%目的 探讨前列腺被膜支动脉阻力指数(RI)与前列腺特异性抗原密度(PSAD)在前列腺癌诊断中的价值.方法 选取我院经直肠超声导向前列腺四区10点法+阳性病灶的组织学活检术和病理检查证实的前列腺疾病患者128例,其中前列腺癌患者63例(前列腺癌组),前列腺增生症患者65例(对照组),经直肠超声检测两组患者被膜支动脉阻力指数(RI)、总前列腺特异性抗原(TPSA)和前列腺体积,并由此计算PSAD,比较分析RI、PSAD诊断前列腺癌的敏感性、特异性、准确性.结果 前列腺癌组被膜支动脉的RI、PSAD均高于对照组,两组比较差异均有统计学意义(P<0.001).前列腺被膜支动脉RI≥0.80诊断前列腺癌的敏感性为82.54%,特异性为72.31%,准确性77.34%;PSAD＞0.30 ng/(ml·cm3)诊断前列腺癌的敏感性为88.89%,特异性为70.77%,准确性为79.69%.结论 前列腺被膜支动脉RI与PSAD均为诊断前列腺癌的可靠筛查指标.