超高速剪切波弹性成像对离体猪肝微波消融效果的评价研究

摘要

目的探讨超高速剪切波弹性成像（SSI）在评价离体猪肝微波消融效果的价值。方法于离体猪肝消融前后分别测量拟消融部位的杨氏模量值；消融结束即刻用二维超声和SSI测量消融灶最大横切面的左右径及前后径。消融结束后将最大横切面的消融灶标本行病理学检查。结果共制备20个消融灶，微波消融前后消融部位的杨氏模量值比较，差异有统计学意义（P＜0.01）；微波消融术后二维超声及SSI测量消融灶最大横切面的左右径比较，差异有统计学意义（P＜0.01）；SSI所测得前后径、左右径与消融灶大体标本测量值比较，差异无统计学意义。结论 SSI能够定量分析微波消融前后离体猪肝的硬度变化，有助于评估微波消融效果；SSI评价微波消融效果优于二维超声。%Objective To investigate the value of supersonic shear imaging (SSI) in assessing the effect of microwave ablation of pork livers in vitro. Methods Yong modulus was measured before and immediately after ablation by SSI. All the antero-posterior and left-right diameters of ablation lesions were measured by 2D ultrasound and SSI in the maximum cross sections immediately after the ablation. The experiment specimens were analyzed by pathological examination after ablation. Results Twenty microwave ablation lesions were established in pork livers in vitro.There were significant differences when comparing the average values of Yong modulus before and after the experiment(P<0.01). The difference between the left-right diameter of the focus measured with 2D ultrasound immediately after the microwave ablation and the left-right diameter of the gross specimen was statistically significant(P<0.01).The difference between the antero-posterior diameter and left-right diameter of the focus measured with SSI immediately after the microwave ablation and the antero-posterior diameter and left-right diameter of the gross specimen was not statistically significant. Conclusion SSI can quantitatively analyze the change of stiffness before and after microwave ablation, and contribute to assess the effect of microwave ablation, it is superior to 2D ultrasound in evaluating the effect of microwave ablation.