CACNA1C基因多态性对硝苯地平治疗老年性高血压疗效的影响

摘要

[Objective]ToobservetheeffectofthepoLymorphismofCACNA1Congeriatrichypertension treatmentwithnifedipine.[Methods]CACNA1C genotyping (rs2222732,rs2239050,rs2239128Locus)was performedin96eLderLypatientswithhypertension.Nifedipine20mg／dwasgivenfor5weeks.Fastingvenous bLoodwascoLLectedbeforeandaftertreatment.FastingbLoodgLucose(FPG),bLoodureanitrogen(BUN),cre-atinine(Cr),systoLicbLoodpressure(SBP),diastoLicbLoodpressure(DBP)andbodymassindex(BMI)were measured.[ResuLts]TherewasnosignificantdifferenceinSBP,DBP,BMI,serum FPG,BUN,CrLeveLof betweenpatientswithdifferentgenotypes (rs2222732,rs2239050,rs2239128Locus)beforeandaftertreat-ment(P>0.05).ThedecreaseofSBP,DBPinTTpatientswithrs2222732LocuswassignificantLyhigherthan thatinpatientswithTG,GGgenotypebeforeandaftertreatment(P<0.05).ThedecreaseofSBP,DBPin rs2239050genotypepatientsbeforeandaftertreatmentwassignificantLyhigherthanthatinGC,CCtypepa-tients(P<0.05).TherewasnosignificantdifferenceinthedecreaseofSBP,DBPbetweengroupsbeforeand aftertreatmentinCT,TT,CCpatientswithrs2239128Locus(P>0.05).[ConcLusion]ThepoLymorphismsof rs2222732andrs2239050LocusofCACNA1CgenehavegreatinfLuenceontheantihypertensiveeffectofnife-dipine.%[目的]探讨L型钙离子通道α1C亚基基因(CACNA1C)基因多态性对硝苯地平治疗老年性高血压临床疗效的影响.[方法]对96例老年性高血压患者进行CACNA1C基因分型(rs2222732、rs2239050、rs2239128位点),给予硝苯地平20mg／d进行治疗,治疗周期为5周.采集所有患者治疗前后空腹静脉血,检测其空腹血糖(FPG)、血尿素氮(BUN)、肌酐(Cr)水平、收缩压(SBP)、舒张压(DBP)及体质量指数(BMI).[结果]不同基因型患者(rs2222732、rs2239050、rs2239128位点)治疗前及治疗后SBP、DBP、BMI,血清FPG、BUN、Cr水平比较,差异均无统计学意义(P>0.05).rs2222732位点TT型患者治疗前后SBP、DBP降低幅度大于TG、GG型患者,差异具有统计学意义(P<0.05).rs2239050位点GG型患者治疗前后SBP、DBP降低幅度大于GC、CC型患者,差异具有统计学意义(P<0.05).rs2239128位点CT、TT、CC型患者治疗前后SBP、DBP降低幅度组间比较,差异无统计学意义(P>0.05).[结论]CACNA1C基因rs2222732、rs2239050位点多态性对硝苯地平降压效果有较大的影响.