老年2型糖尿病合并轻度认知功能损害的随访研究

摘要

[目的]探讨老年2型糖尿病(T2DM)合并轻度认知功能损害(MCI)患者认知功能的变化特点.[方法]研究对象为患MCI的老年T2DM患者(MCI组,n=48)和认知功能正常的老年健康对照组(对照组,n=48).采用蒙特利尔认知评估表(MoCA)北京版、简易精神状态量表(MMSE)和画钟测验(CDT)行神经心理评估,在初次确诊及随访一年后评价分析比较.[结果]一年后随访,MCI组MoCA量表总分、视空间与执行功能、语言、延迟回忆评分、MMSE量表总分和CDT得分与基线得分比较均有不同程度下降,其中MoCA量表总分、视空间与执行功能、延迟回忆评分随访后与基线间差异均有统计学意义(P<0.05),且与对照组同期比较差异有显著性(P<0.05);对照组MoCA量表总分、视空间与执行功能、延迟回忆评分、MMSE量表总分和CDT得分与基线得分比较均有不同程度下降,但差异无统计学意义(P>0.05).[结论]延迟回忆和视空间与执行功能受损是老年T2DM合并MCI的早期特征性表现.%[Objective]To observe and evaluate the changes of cognitive function of elderly type 2 diabetes mellitus(T2DM) with mild cognitive impairment(MCI). [Methods]A total of 48 elderly T2DM patients with MCKMCI group, n =48) and 48 elderly healthy controls with normal cognition(control group, n =48) were selected. Montreal cognitive assessment(MoCA)(Beijing edition) , mini mental state examination(MMSE)and clock drawing test(CDT) were used for neuropsychology assessment. All patients were evaluated and compared at initial definitive diagnosis and a year after follow up. [Results]Compared with baseline scores, the total score of MoCA, visuospatial skill, executive function, language, delayed recall score, total score of MMSK and CDT score in MCI group after a year of follow up decreased at difference degrees, and there were significant differences ( P <0. 05). Compared with baseline scores, the total score of MoCA, visuospatial skill, executive function, delayed recall score, total score of MMSE and CDT score in control group decreased at different degrees, but there was no significant difference( P >0. 05). [Conclusion]Delayed recall, visuospatial and executive impairment are the early characteristic manifestations of elderly T2DM with MCI.