抗炎联合仙方活命饮加减治疗急性盆腔炎疗效观察

摘要

[Objective]To explore the efficacy of antiinflammatory therapy combined with modified Xian-fang Huoming decoction for the treatment of acute pelvitis.[Methods]A total of 50 patients with acute pelvitis were collected and randomly divided into two groups.The control group was given routine treatment,while the observation group was given the modified Xianfang Huoming decoction based on the treatment of the con-trol group.Clinical efficacy and serum levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor nec-rosis factor-alpha(TNF-α)after treatment were compared between two groups.[Results]Before treatment, the main pathogens in two groups were aerobic bacteria, anaerobic bacteria, mycoplasma urealytium, Chlamydia trachomatis and gram-positive neisseria gonorrhoeae.After treatment,the positive rate of myco-plasma urealytium in observation group was markedly lower than that in control group,and there was signifi-cant difference between two groups(P <0.05).After a course of treatment,the total effective rate was 92.0%(23/25),which was markedly higher than that in control group(90.0%,20/25 ),and there was significant difference(χ2=5.980,P <0.05).After treatment,serum levels of CRP,IL-6 and TNF-αwere decreased.Af-ter treatment for 3d,5d,7d and 10d,serum levels of CRP,IL-6 and TNF-α in observation group were markedly lower than those in control group,and there was significant difference(P <0.05).[Conclusion]The main pathogens of acute pelvitis are aerobic bacteria,mycoplasma urealytium,Chlamydia trachomatis and an-aerobic bacteria.The combined treatment of traditional Chinese medicine and western medicine such as antiin-flammatory therapy combined the modified Xianfang Huoming Decoction can decrease the positive rate of anae-robic bacteria and Chlamydia trachomatis ,and reduce inflammatory response.%【目的】探讨抗炎联合仙方活命饮加减治疗急性盆腔炎的疗效。【方法】收集急性盆腔炎患者50例,随机分为两组：对照组给予常规治疗,观察组在对照组基础上采用仙方活命饮加减治疗。两组治疗前后取阴道分泌物检测感染病原体类型,比较两组患者治疗后的临床疗效及血清 C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。【结果】治疗前两组主要病原体包括需氧菌、厌氧菌、解脲支原体、沙眼衣原体和革兰阳性淋球菌,治疗后观察组厌氧菌、解脲支原体阳性率显著低于对照组,两组比较差异具有统计学意义(P <0.05)。1个疗程后,观察组总有效率为92.0%(23/25),显著高于对照组80.0%(20/25),差异有统计学意义(χ2=5.980,P <0.05)；治疗后患者血清 CRP、IL-6、TNF-α水平呈降低趋势,观察组治疗后3 d、5 d、7 d、10 d 血清 CRP、IL-6、TNF-α水平均显著低于对照组,差异有统计学意义(P <0.05)。【结论】急性盆腔炎主要病原体分别是需氧菌、解脲支原体、沙眼衣原体和厌氧菌,抗炎联合仙方活命饮加减的中西结合治疗可降低厌氧菌、解脲支原体阳性率,减轻炎症反应。