喉癌分子切缘及临床因素与喉癌预后的相关性

摘要

[目的]探讨喉癌分子切缘及临床因素与喉癌预后的相关性.[方法]收集2010年1月至2011年12月于本院行手术治疗的喉癌患者129例的临床资料,均随访至2016年9月或至终点事件死亡.以是否复发分为两组,复发组47例,未复发组82例;探讨两组喉癌分子切缘及临床因素与预后的相关性.[结果]复发组T3～T4期,中、低分化癌,伴颈淋巴结转移,肿瘤位于声门下的构成比例明显高于未复发组,差异有统计学意义(P＜0.05).两组性别、年龄、术后放疗比较差异无统计学意义(P＞0.05).复发组cyclind1表达(+++)、(+)构成比例明显高于未复发组,差异有统计学意义(P＜0.05).复发组P27阳性表达率低于未复发组,P53、eIF4E阳性表达率高于未复发组,差异有统计学意义(P＜0.05).建立直线回归方程,经Spearman关系检验结果显示,分子切缘cy-clind1表达与预后呈正相关(r＝0.716,P＝0.002);P53、eIF4E与预后呈正相关(r＝0.616,0.928,P＝0.014,0.000);P27与预后呈负相关(r＝－0.741,P＝0.012).[结论]喉癌分子切缘与预后密切相关,同时伴颈淋巴结转移、T分期高、肿瘤位于声门下是影响喉癌预后的主要因素.%[Objective] To investigate the relationship between molecular cutting edge and clinical factors of la-ryngeal carcinoma and its prognosis.[Methods]The clinical data of 129 patients with laryngeal cancer who under-went surgical treatment from January 2010 to December 2011 were collected.All patients were followed up until September 2016 or death at the end of the year,and were divided into two groups according to recurrent or not :recurrence group(47 cases)and non recurrence group(82 cases).The correlation between the molecular margin and clinical factors of the two groups of laryngocarcinoma and prognosis were discussed.[Results]The proportion of subglottic tumor in T3～T4stage,middle and low differentiation carcinoma with cervical lymph node metastasis was significantly higher than that in the non-recurrence group(P ＜0.05).There was no significant difference in sex,age and postoperative radiotherapy between the two groups(P ＞0.05).The expression of cyclind1(+++)and(++)composition ratio in the recurrent group was significantly higher than that in the non-recurrence group(P ＜0.05).The positive expression rate of P27 in the recurrent group was lower than that in the non-recurrent group(P ＜0.05).The positive expression rate of P53 eIF4E was significantly higher than that of the non-recurrence group(P ＜0.05).The linear regression equation was established.The results of Spearman relation test showed that the expression of cyclind1 in the molecular cutting edge was positively correlated with the prognosis(r ＝0.716,P ＝0.002).P53 and eIF4E were positively correlated with the prognosis(r ＝ 0.616,0.928,P ＝ 0.014,0.000)and there was a negative correlation between the P27 and the prognosis(r ＝ －0.741,P ＝0.012).[Conclu-sion]The molecular cut edge of laryngeal carcinoma is closely related to prognosis.At the same time,cervical lymph node metastasis accompanied,higher T stage and tumor located in the subglottic are the main factors affect-ing the prognosis of laryngeal carcinoma.