[Objective]To investigate the clinicopathological features and long-term prognosis of endome-triosis malignant transformations(EMS)to reveal its differences from ovarian cancer.[Methods]Eighty pa-tients with EMS malignant ovarian cancer(observation group)and 80 patients with non-EMS malignant ovari-an cancer(control group)who were in our hospital from January 2009 to January 2012 were selected.The clin-icopathological characteristics and prognosis of the two groups were compared.[Results]The proportion of pa-tients less than 50 years old in the observation group was higher than that in the control group(P <0.05). The proportion of patients with stage Ⅲ ~ Ⅳ and serum CA-125> 1000 U /mL was lower than that of the control group(P <0.05).The other indicators in the two groups were also statistically significant differences (P <0.05).The 5-year survival rate was 68.75%(55/80)in the observation group,which was significantly higher than that in the control group(50.00%,40/80);the difference was statistically significant(χ2=5.830, P =0.016).The 5-year survival rate was taken as the dependent variable,with age,irregular vaginal bleed-ing,tumor diameter,FIGO stage,pathological type,CA125,whether EMS malignant as independent varia-bles.Logistic regression analysis showed that FIGO hyperplasia,serous adenocarcinoma and CA125> 1000 IU/mL were independent risk factors for poor prognosis in patients with ovarian cancer(P < 0.05).The prognosis of patients with EMS malignant lesions was relatively better than that of non-EMS malignant ovarian cancer patients(OR=0.682,P <0.05).[Conclusion]The clinical features of patients with malignant change of EMS are quite different from the clinical pathological characteristics of patients with non EMS malignant trans-formed ovarian cancer.Patients with EMS malignancy have a better prognosis than patients with non-EMS ma-lignant ovarian cancer.%[目的]探讨卵巢子宫内膜异位症(EM S)恶变患者的临床病理学特征、远期预后与卵巢癌患者的差异.[方法]选取本院2009年1月至2012年1月收集的EM S恶变卵巢癌患者(观察组)80例、非 EM S恶变卵巢癌患者(对照组)80例,对比两组患者的临床病理学特征及远期预后.[结果]观察组患者年龄≤50岁患者的比例高于对照组(P <0.05);Ⅲ + Ⅳ期、血清CA-125水平>1000 U/mL患者比例低于对照组(P <0.05);两组其他指标比较差异也均具有统计学意义(P <0.05);观察组患者的5年生存率68.75%(55/80),显著高于对照组的50.00%(40/80),其差异均有统计学意义(χ2=5.830,P =0.016);以5年生存率为因变量,以年龄、阴道是否不规则出血、肿瘤直径、FIGO 分期、病理学类型、CA125、是否 EMS恶变作为自变量.Logistic回归分析显示:FIGO高分期、浆液性腺癌、CA125>1000 IU/mL是卵巢癌患者的不良预后的独立危险因素(P <0.05),EM S恶变患者相对于非EM S恶变卵巢癌患者的预后较好(OR值为0.682,P <0.05).[结论]EM S恶性变患者的临床特征与非EM S恶变的卵巢癌患者的临床病理特征差异明显,EM S恶变患者相对于非EM S恶变卵巢癌患者的预后较好.
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