Objective To understand the pathogen's transition, distribution and drag sensitivity of lower respiratory tract bacterial infections during recent 16 years. Methods The sputum of those patients with lower respiratory infection was cultured, and the positive samples were analyzed. Results 4762 strains were isolated, which included 550 strains of gram-positive bacteria (11. 55% ) and 4212 strains of gram-negative bacteria ( 88. 45% ). Staphylococcus aureus accounted for 31. 09% in the gram - positive bacteria, and pseudo-monas aeruginosa took up 23. 93% in the gram -negative bacteria. Staphylococcus aureus was only sensitive to the following medicines, including vancomycin, linezolid, chloramphenicol, doxycycline and cotrimoxazole, and pseudomonas aeruginosa showed its sensitivity mostly to meropenem, cefoperazone and amikacin. Conclusion In respiratory ward, the most common bacteria are staphylococcus aureus and pseudomonas aeruginosa, both of which show drug resistance to the most commonly used antibiotics.%目的 了解我院近16年呼吸科病房下呼吸道细菌感染的病原体的变迁、分布及药敏差异.方法 对呼吸病房下呼吸道感染住院患者痰菌(或支纤镜吸取分泌物)培养阳性标本结果进行分析.结果 分离出菌株共4762株,其中革兰阳性菌550株,占11.55%,革兰阴性菌4212株,占88.45%,金黄色葡萄球菌占革兰阳性菌感染的31.09%;铜绿假单胞菌占革兰阴性菌感染的23.93%;金黄色葡萄球菌目前仅对万古霉素、利奈唑胺、氯霉素强力霉素、复方新诺明的敏感性较好;铜绿假单胞菌目前仅对美罗培南、头孢哌酮舒巴坦、阿米卡星有较高的敏感率.结论 呼吸科病房下呼吸道革兰阳性菌感染居首位的是金黄色葡萄球菌,革兰阴性菌感染居首位的是铜绿假单胞菌,二者均对大多数常用抗菌药物耐药.
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