Objective To investigate and analyze the situation of nosocomial infection in patients with lung cancer during intravenous chemotherapy. Methods The situation of nosocomial infection in 95 lung cancer patients after chemotherapy was retrospectively analyzed. Results A total of 103 pathogen strains were co-cultivated from the specimens of 95 cases. The main pathogenic bacteria were gram-negative bacteria (56. 3%) and gram-positive coc-cus (29. 12%). Statistical analysis confirmed that the nosocomial infection rate was obviously related with tumor clinical stage, invasive procedures or indwell catheters ( deep venous and urethral catheters) , use of imunosuppressor or glucocorticoid, underlying diseases ( such as COPD or diabetes mellitus) . Conclusion The main pathogenic bac-teria of nosocomial infection in lung cancer patients after chemotherapy are gram-negative bacteria, which has impor-tant roles in guiding clinical drug use.%目的：对肺癌化疗患者发生医院感染的状况进行调查分析。方法对95例肺癌患者发生医院感染的状况进行分析。结果95例肺癌化疗患者送检标本中培养出病原菌103株，病原菌以革兰氏阴性杆菌为主(56．3%)，其次为革兰氏阳性球菌(29．12%)；感染的相关因素有：肺癌临床分期、侵袭性操作或导管留置(深静脉导管及导尿管)、同时使用免疫抑制剂或激素、伴有基础疾病(如COPD或糖尿病)。结论肺癌化疗患者医院感染病原菌以革兰氏阴性杆菌为主，合理控制院内感染的相关因素，对指导临床合理用药具有重要意义。
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