136例结核病患者一线抗结核药物耐药监测结果分析

摘要

Objective To evaluate the monitoring results of resistance to first-line anti-tuberculosis drugs in tuberculosis patients in our hospital, and to provide the reference for clinical tuberculosis control and application. Methods Retrospective analysis were carried out in 440 tuberculosis patients who were confirmed to be positive my-cobacterium tuberculosis from January 2012 to December 2014 in our hospital. Results 136 patients were resisted to the first-line anti-tuberculosis drugs, and the total drug resistance rate was 30. 9% . The initial drug resistance rate was 20. 3% , and the resistance rate of the retreatment group was 52. 8% . The resistance to four first-line anti tuber-culosis drugs from high to low was SM, INH, RFP and EMB, and the initial group was SM, INH, RFP and EMB, while the retreatment group was INH, SM, RFP and EMB. Conclusion The resistance to the first-line anti-tubercu-losis drugs in pulmonary tuberculosis patients is high, and the drug-resistance ratio of the retreatment group is signifi-cantly higher than that of the initial group. We should regulate the treatment of tuberculosis in clinical work, formu-late the reasonable scheme of anti-tuberculosis treatment, and reduce the occurrence of drug resistance.%目的：分析我院结核病患者对一线抗结核药物的耐药监测结果,为我市结核病控制及用药提供参考。方法回顾性分析我院2012年1月~2014年12月期间门诊及住院肺结核患者结核分枝杆菌培养阳性440例的临床资料。结果136例患者对一线抗结核药物耐药,总耐药率为30．9%,初始耐药率为20．3%,获得性耐药率为52．8%,对四种一线抗结核药物的耐药率由高到低依次为：SM > INH > RFP > EMB。初治组耐药率依次为 SM > INH > RFP > EMB,复治组耐药率依次为 INH > SM > RFP > EMB。结论我院肺结核患者一线抗结核药物的耐药性较高,复治组患者耐药比例明显高于初治组患者,在临床工作中应规范结核病的治疗,制定合理的抗结核治疗方案,减少耐药发生。