目的：对比静脉使用不同剂量甲强龙对小儿重症支原体肺炎的疗效，探讨更佳的治疗方案。方法将46例重症支原体肺炎患儿随机分为冲击剂量组及常规剂量组。除常规治疗外，冲击剂量组静脉给予甲强龙15~30 mg/(kg·d)，常规剂量组静脉给予甲强龙1~2mg/(kg·d)，均连续用3 d后改强的松口服。结果冲击剂量组和常规剂量组总有效率分别为95．7%和73．9%，统计学差异显著( P<0．05)。冲击剂量组在发热、咳嗽、肺部体征改善时间及胸部X线片恢复时间上明显低于对照组( P<0．05)。结论治疗小儿重症支原体肺炎时，冲击剂量甲强龙疗效优于常规剂量。%Objective To observe the clinical effect of different dose of methylprednisolone in the treatment of children with severe mycoplasma pneumonia. Methods 46 children with SMP were randomly divided into the high dose group and the routine dose group. Both groups were treated with the same symptomatic therapies. In addition to the basic treatment, the high dose group was given methylprednisolone 15~30mg/(kg. d) by intravenous drip, while the routine dose group was given methylprednisolone 1~2mg/( kg. d) by intravenous drip, and oral prednisone in-stead after three days for both groups. Results The total effective rate was 95. 7% in the high dose group and 73. 9% in the routine dose group (P<0. 05). The duration of fever, cough relief time and pulmonary shadow absorption time on chest X-ray were significantly shorter in the high dose group than in the routine dose group (P<0. 05). Conclusion The treatment of high dose methylprednisolone is superior to routine dose therapy for SMP in children.
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