哮喘患儿治疗前后血清不同促炎因子和抗炎因子水平改变的临床意义研究

摘要

目的 探讨哮喘患儿治疗前后血清不同促炎因子和抗炎因子水平改变的临床意义.方法 连续性收录80例哮喘急性发作患儿,综合分析比较治疗前后血清促炎因子(IFNγ,TNFα,IL-1β以及Il-6)和抗炎因子(IL-10,TGFβ以及IL-4)水平改变.结果 哮喘患儿治疗前血清IFNγ,TNFα以及IL-6等促炎因子水平高于对照组(P<0.05).经治疗后,血清IFNγ和Il-6水平下降最为明显(P<0.05).哮喘患儿治疗前血清IL-10和IL-4等抗炎因子水平低于对照组(P<0.05).经治疗后,血清IL-10和IL-4水平上升最为明显(P<0.05).危重亚组患儿血清IFNγ和IL-6水平明显高于轻度亚组(P<0.05).哮喘分级和促炎因子TNFα呈负相关(r=-0.589,P<0.05).促炎因子TNFα与IL-6(r=0.599,P<0.05),IL-1β 与IL-6(r=0.532,P<0.05)之间存在正相关.促炎因子TNFα与抗炎因子TGFβ呈负相关(r=-0.662,P<0.05).结论 哮喘患儿血清IFNγ、IL-6、IL-10和IL-4水平在治疗过程中动态变化,与哮喘严重程度密切相关.%Objective To explore the clinical significance of serum inflammatory cytokines and anti-inflammatory cytokines of children with acute episode of bronchial asthma before and after treatment. Methods 80 children with acute episode of bronchial asthma were enrolled in this study. The changes in serum inflammatory cytokines(IFN-γ, TNF-α, IL-1βand Il-6)and anti-inflammatory cytokines(IL-10, TGF-βand IL-4)were measured and analyzed be-fore and after treatment. Results The levels of serum IFN-γ, TNF-αand IL-6 in the asthma group were significantly higher than those in the control group(P<0. 05). After the treatment, the contents of serum IFN-γ and IL-6 de-creased(P<0. 05). The levels of serum IL-10 and IL-4 in the asthma group were significantly lower than those in the control group(P<0. 05). The contents of serum IL-10 and IL-4 increased(P<0. 05). Correlation analysis showed that TNF-αwas negatively associated with asthma classification(r= -0. 589, P<0. 05)and TGF-β(r= -0. 662, P<0. 05)respectively. Conclusion The levels of serum IFN-γ, IL-6, IL-10 and IL-4 in children with a-cute episode of bronchial asthma are dynamic changes following treatment and related with the severity of asthma.