Pyrimidine derivative, agents for curing an allergic disease, asthma and atopic dermatitis, agents for inhibiting the production of tnf-alpha, cytokines and 5-lipoxygenase, processes for curing an allergic disease, asthma and atopic dermatitis and to inhibit the production of no, tnf-alpha and cytokines and 5-lipoxygenase and uses of a compound

摘要

"PYRIMIDINE DERIVATIVE, AGENTS FOR THE CURE OF AN ALLERGIC DISEASE, ASTHMA AND AN AOPIC DERMATITIS, AGENTS FOR THE INHIBITION OF THE PRODUCTION OF TNF-ALPHA, CYTOKINES AND 5-LIPOXYGENASE, AND USES OF A COMPOUND". The present invention provides a new pyrimidine derivative represented by the general formula (1), in which R, R ^ 4 ^ and R ^ 8 ^ are as defined in the description, or their pharmaceutically acceptable salt, which has excellent activity to inhibit NO (nitrogen oxide) formation in vivo.